Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids

Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids

Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cancer cell proliferation by suppressing the mevalonate pathway. However, because of its low oral absorption, high doses of ATV are required for chemotherapeutic applications. In t...

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Bibliographic Details
Main Authors: Laxman Subedi, Prashant Pandey, Bikram Khadka, Jung-Hyun Shim, Seung-Sik Cho, Seho Kweon, Youngro Byun, Ki-Taek Kim, Jin Woo Park
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Drug Delivery
Subjects:
Atorvastatin
nanoemulsion
bile acid-mediated uptake
multivitamin-facilitated transport
oral bioavailability
oral chemotherapy
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2149896

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