GRB2, a protein known for a long time with a new autophagy-regulating function
ABSTRACTBECN1 (BCL2 interacting myosin like coiled protein) is a major regulator of autophagy and a haploinsufficient tumor suppressor. BECN1 binds to multiple proteins and it is part of at least two different class III phosphatidylinositol (PI) 3 Kinase (PI3KC3) complexes that regulate autophagy an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Autophagy Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2024.2325265 |
| Summary: | ABSTRACTBECN1 (BCL2 interacting myosin like coiled protein) is a major regulator of autophagy and a haploinsufficient tumor suppressor. BECN1 binds to multiple proteins and it is part of at least two different class III phosphatidylinositol (PI) 3 Kinase (PI3KC3) complexes that regulate autophagy and endocytic trafficking through the biosynthesis of phosphatidylinositol-3-phosphate. BECN1 and the activity of the PI3KC3 are regulated by post-translational modifications and/or subcellular localization. We recently discovered that GRB2 (growth factor receptor bound protein 2), an adaptor protein of several tyrosine kinases, interacts with BECN1 and regulates autophagy.1 |
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| ISSN: | 2769-4127 |