Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i>
<i>Trichophyton indotineae</i> causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant <i>Trichophyton indotineae</i> strains with mutations in the squalene epoxidase gene is a major issue. This emerging species is now more frequently isola...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/7/733 |
| _version_ | 1827732721436196864 |
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| author | Giuseppe Russo Laurence Toutous Trellu Lionel Fontao Béatrice Ninet |
| author_facet | Giuseppe Russo Laurence Toutous Trellu Lionel Fontao Béatrice Ninet |
| author_sort | Giuseppe Russo |
| collection | DOAJ |
| description | <i>Trichophyton indotineae</i> causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant <i>Trichophyton indotineae</i> strains with mutations in the squalene epoxidase gene is a major issue. This emerging species is now more frequently isolated in Europe and we report here two cases of <i>T. indotineae</i> tinea corporis in Switzerland, one with in vitro resistance to terbinafine and a second with in vitro susceptibility but a clinical resistance. Mycology isolation from cultures and sequencing ITS gene were used to confirm <i>T. indotineae</i> infection. In vitro antifungal susceptibility was tested in a microplate with a colorimetric detection of fungal viability for the determination of the minimal inhibitory concentration (MIC). Facing these emerging resistances and since there are a limited number of antifungal agents available to treat dermatophytosis, the early detection of terbinafine resistance should be a prerequisite in the management of <i>T. indotineae</i> infections. |
| first_indexed | 2024-03-11T00:56:02Z |
| format | Article |
| id | doaj.art-b9fc92197cc14a65abe4fafa65aebd02 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-11T00:56:02Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b9fc92197cc14a65abe4fafa65aebd022023-11-18T20:01:38ZengMDPI AGJournal of Fungi2309-608X2023-07-019773310.3390/jof9070733Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i>Giuseppe Russo0Laurence Toutous Trellu1Lionel Fontao2Béatrice Ninet3Division of Dermatology and Venereology, University Hospital of Geneva, CH-1205 Geneva, SwitzerlandDivision of Dermatology and Venereology, University Hospital of Geneva, CH-1205 Geneva, SwitzerlandDivision of Dermatology and Venereology, University Hospital of Geneva, CH-1205 Geneva, SwitzerlandLaboratory of Dermatology, Division of Laboratory Medicine, University Hospital of Geneva, CH-1205 Geneva, Switzerland<i>Trichophyton indotineae</i> causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant <i>Trichophyton indotineae</i> strains with mutations in the squalene epoxidase gene is a major issue. This emerging species is now more frequently isolated in Europe and we report here two cases of <i>T. indotineae</i> tinea corporis in Switzerland, one with in vitro resistance to terbinafine and a second with in vitro susceptibility but a clinical resistance. Mycology isolation from cultures and sequencing ITS gene were used to confirm <i>T. indotineae</i> infection. In vitro antifungal susceptibility was tested in a microplate with a colorimetric detection of fungal viability for the determination of the minimal inhibitory concentration (MIC). Facing these emerging resistances and since there are a limited number of antifungal agents available to treat dermatophytosis, the early detection of terbinafine resistance should be a prerequisite in the management of <i>T. indotineae</i> infections.https://www.mdpi.com/2309-608X/9/7/733<i>Trichophyton indotineae</i>terbinafine-resistancedermatophyte infectiontinea corporisantifungal susceptibility |
| spellingShingle | Giuseppe Russo Laurence Toutous Trellu Lionel Fontao Béatrice Ninet Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> Journal of Fungi <i>Trichophyton indotineae</i> terbinafine-resistance dermatophyte infection tinea corporis antifungal susceptibility |
| title | Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> |
| title_full | Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> |
| title_fullStr | Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> |
| title_full_unstemmed | Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> |
| title_short | Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i> |
| title_sort | towards an early clinical and biological resistance detection in dermatophytosis about 2 cases of i trichophyton indotineae i |
| topic | <i>Trichophyton indotineae</i> terbinafine-resistance dermatophyte infection tinea corporis antifungal susceptibility |
| url | https://www.mdpi.com/2309-608X/9/7/733 |
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