Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation.
The purpose of this study was to assess the effects of berberine (BBR) on thermoregulation in mice exposed to hot (40°C) and cold (4°C) environmental conditions. Four groups of mice were assembled with three different dosages of BBR (0.2, 0.4, and 0.8 mg/kg) and normal saline (control). In room temp...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3545878?pdf=render |
| _version_ | 1818504237484605440 |
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| author | Jing-Fei Jiang Yu-Gang Wang Jun Hu Fan Lei Michael M Kheir Xin-Pei Wang Yu-Shuang Chai Zhi-Yi Yuan Xi Lu Dong-Ming Xing Feng Du Li-Jun Du |
| author_facet | Jing-Fei Jiang Yu-Gang Wang Jun Hu Fan Lei Michael M Kheir Xin-Pei Wang Yu-Shuang Chai Zhi-Yi Yuan Xi Lu Dong-Ming Xing Feng Du Li-Jun Du |
| author_sort | Jing-Fei Jiang |
| collection | DOAJ |
| description | The purpose of this study was to assess the effects of berberine (BBR) on thermoregulation in mice exposed to hot (40°C) and cold (4°C) environmental conditions. Four groups of mice were assembled with three different dosages of BBR (0.2, 0.4, and 0.8 mg/kg) and normal saline (control). In room temperature, our largest dosage of BBR (0.8 mg/kg) can reduce rectal temperatures (Tc) of normal mice. In hot conditions, BBR can antagonize the increasing core body temperature and inhibit the expression of HSP70 and TNFα in mice; conversely, in cold conditions, BBR can antagonize the decreasing core body temperature and enhance the expression of TRPM8. This study demonstrates the dual ability of BBR in maintaining thermal balance, which is of great relevance to the regulation of HSP70, TNFα and TRPM8. |
| first_indexed | 2024-12-10T21:34:28Z |
| format | Article |
| id | doaj.art-b9fcacba100544f19f8ae764f43b5fe3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T21:34:28Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b9fcacba100544f19f8ae764f43b5fe32022-12-22T01:32:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5423410.1371/journal.pone.0054234Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation.Jing-Fei JiangYu-Gang WangJun HuFan LeiMichael M KheirXin-Pei WangYu-Shuang ChaiZhi-Yi YuanXi LuDong-Ming XingFeng DuLi-Jun DuThe purpose of this study was to assess the effects of berberine (BBR) on thermoregulation in mice exposed to hot (40°C) and cold (4°C) environmental conditions. Four groups of mice were assembled with three different dosages of BBR (0.2, 0.4, and 0.8 mg/kg) and normal saline (control). In room temperature, our largest dosage of BBR (0.8 mg/kg) can reduce rectal temperatures (Tc) of normal mice. In hot conditions, BBR can antagonize the increasing core body temperature and inhibit the expression of HSP70 and TNFα in mice; conversely, in cold conditions, BBR can antagonize the decreasing core body temperature and enhance the expression of TRPM8. This study demonstrates the dual ability of BBR in maintaining thermal balance, which is of great relevance to the regulation of HSP70, TNFα and TRPM8.http://europepmc.org/articles/PMC3545878?pdf=render |
| spellingShingle | Jing-Fei Jiang Yu-Gang Wang Jun Hu Fan Lei Michael M Kheir Xin-Pei Wang Yu-Shuang Chai Zhi-Yi Yuan Xi Lu Dong-Ming Xing Feng Du Li-Jun Du Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. PLoS ONE |
| title | Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. |
| title_full | Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. |
| title_fullStr | Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. |
| title_full_unstemmed | Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. |
| title_short | Novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation. |
| title_sort | novel effect of berberine on thermoregulation in mice model induced by hot and cold environmental stimulation |
| url | http://europepmc.org/articles/PMC3545878?pdf=render |
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