Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior
The present study included the construction of polygenic risk score (PRS) models of individual differences in anxiety level, which increased values represent the endophenotype of depression and suicidal behavior, to predict these psychopathologies based on genotyping of 63 SNPs of serotoninergic, hy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/315 |
| _version_ | 1797694467998744576 |
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| author | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. G. Valinurov I. Yu. Ahmerova I.Yu. S. B. Malykh M. M. Lobaskova E. K. Khusnutdinova |
| author_facet | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. G. Valinurov I. Yu. Ahmerova I.Yu. S. B. Malykh M. M. Lobaskova E. K. Khusnutdinova |
| author_sort | A. V. Kazantseva |
| collection | DOAJ |
| description | The present study included the construction of polygenic risk score (PRS) models of individual differences in anxiety level, which increased values represent the endophenotype of depression and suicidal behavior, to predict these psychopathologies based on genotyping of 63 SNPs of serotoninergic, hypothalamicpituitary-adrenal and neurotrophic factors systems together with the relative leukocyte telomere length. According to logistic regression analysis, PRS models of individual differences in Neuroticism (EPI) level (P<0,2) predicted decreased risk of unipolar depression (P0.2=0,033, β=-5,24, r2=0,78) in women, which points to the necessity to consider sex during polygenic risk score analysis. |
| first_indexed | 2024-03-12T02:58:25Z |
| format | Article |
| id | doaj.art-ba0020eb36d945c8ab82a4cfae3e453d |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2024-03-12T02:58:25Z |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-ba0020eb36d945c8ab82a4cfae3e453d2023-09-03T15:08:42ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1828310.31363/2313-7053-2019-4-1-82-83294Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behaviorA. V. Kazantseva0R. F. Enikeeva1Yu. D. Davydova2R. G. Valinurov3I. Yu. Ahmerova I.Yu.4S. B. Malykh5M. M. Lobaskova6E. K. Khusnutdinova7Institute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesInstitute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesInstitute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesRepublican Clinical Psychiatric HospitalRepublican Clinical Psychiatric HospitalPsychological Institute, Russian Academy of EducationPsychological Institute, Russian Academy of EducationInstitute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesThe present study included the construction of polygenic risk score (PRS) models of individual differences in anxiety level, which increased values represent the endophenotype of depression and suicidal behavior, to predict these psychopathologies based on genotyping of 63 SNPs of serotoninergic, hypothalamicpituitary-adrenal and neurotrophic factors systems together with the relative leukocyte telomere length. According to logistic regression analysis, PRS models of individual differences in Neuroticism (EPI) level (P<0,2) predicted decreased risk of unipolar depression (P0.2=0,033, β=-5,24, r2=0,78) in women, which points to the necessity to consider sex during polygenic risk score analysis.https://www.bekhterevreview.com/jour/article/view/315depression, suicide, polygenic risk score, leukocyte telomere length |
| spellingShingle | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. G. Valinurov I. Yu. Ahmerova I.Yu. S. B. Malykh M. M. Lobaskova E. K. Khusnutdinova Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева depression, suicide, polygenic risk score, leukocyte telomere length |
| title | Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| title_full | Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| title_fullStr | Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| title_full_unstemmed | Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| title_short | Polygenic risk score models based on anxiety-related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| title_sort | polygenic risk score models based on anxiety related traits as endophenotypes to predict unipolar depression and suicidal behavior |
| topic | depression, suicide, polygenic risk score, leukocyte telomere length |
| url | https://www.bekhterevreview.com/jour/article/view/315 |
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