The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age
Side effects such as hypotension and cerebral perfusion disorder may be encountered after anaesthesia induction, especially in elderly patients. Some studies have attempted to determine whether hypotension during induction and associated organ perfusion disorders can be prevented when propofol is us...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2020-03-01
|
| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=51082 |
| _version_ | 1797327716974854144 |
|---|---|
| author | Harun Tolga Duran Ersin Koksal Yasemin Burcu Ustun Sezgin Bilgin Fatih Ozkan |
| author_facet | Harun Tolga Duran Ersin Koksal Yasemin Burcu Ustun Sezgin Bilgin Fatih Ozkan |
| author_sort | Harun Tolga Duran |
| collection | DOAJ |
| description | Side effects such as hypotension and cerebral perfusion disorder may be encountered after anaesthesia induction, especially in elderly patients. Some studies have attempted to determine whether hypotension during induction and associated organ perfusion disorders can be prevented when propofol is used in combination with ketamine. However, no study has come to light investigating the effects of ketamine added to propofol on cerebral oximetry. The present study aimed to compare the effects of anaesthesia induction with propofol or propofol+ketamine (ketofol) on haemodynamic changes and cerebral oximetry in elderly patients undergoing anaesthesia induction.
A total of 40 patients were randomly divided into two groups. Cerebral oximetry sensors were placed in the right and left of the frontal region. Patients in Group P were treated with 1.5 mg/kg propofol IV induction and patients in Group K were treated with the 0.2 ml/kg ketofol IV. The patients in both groups received 0.5 mg/kg lidocaine, 0.6 mg/kg rocuronium and a 0.1 mcg/kg/min infusion of remifentanil. Heart rate (HR), systolic, diastolic and mean arterial pressure (SBP, DBP, MAP) and cerebral oxygen saturation (RSO2) values before and 1, 3, 5, 10, 30 and 60 minutes after induction were recorded.SBP, DBP and MAP values were significantly lower in the propofol group at 1, 3 and 5 minutes after induction (p < 0.05). The right-side RSO2 values were significantly lower at 3 and 5 minutes after induction in the propofol group compared to the ketofol group and the left-side RSO2 values were similarly significantly lower after 1, 3 and 5 minutes (p < 0.05). Ketofol used in anaesthesia induction has less effect than propofol on mean arterial pressure and cerebral oxygen saturation values. Therefore, ketofol appears to be a good choice for use in anaesthesia induction in elderly patients. [Med-Science 2020; 9(1.000): 21-5] |
| first_indexed | 2024-03-08T06:42:30Z |
| format | Article |
| id | doaj.art-ba0028efe4294a70bebfdbd13a44f890 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:42:30Z |
| publishDate | 2020-03-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-ba0028efe4294a70bebfdbd13a44f8902024-02-03T08:37:00ZengSociety of Turaz BilimMedicine Science2147-06342020-03-019121510.5455/medscience.2019.08.912851082The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of ageHarun Tolga Duran0Ersin KoksalYasemin Burcu UstunSezgin BilginFatih OzkanOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, TurkeySide effects such as hypotension and cerebral perfusion disorder may be encountered after anaesthesia induction, especially in elderly patients. Some studies have attempted to determine whether hypotension during induction and associated organ perfusion disorders can be prevented when propofol is used in combination with ketamine. However, no study has come to light investigating the effects of ketamine added to propofol on cerebral oximetry. The present study aimed to compare the effects of anaesthesia induction with propofol or propofol+ketamine (ketofol) on haemodynamic changes and cerebral oximetry in elderly patients undergoing anaesthesia induction. A total of 40 patients were randomly divided into two groups. Cerebral oximetry sensors were placed in the right and left of the frontal region. Patients in Group P were treated with 1.5 mg/kg propofol IV induction and patients in Group K were treated with the 0.2 ml/kg ketofol IV. The patients in both groups received 0.5 mg/kg lidocaine, 0.6 mg/kg rocuronium and a 0.1 mcg/kg/min infusion of remifentanil. Heart rate (HR), systolic, diastolic and mean arterial pressure (SBP, DBP, MAP) and cerebral oxygen saturation (RSO2) values before and 1, 3, 5, 10, 30 and 60 minutes after induction were recorded.SBP, DBP and MAP values were significantly lower in the propofol group at 1, 3 and 5 minutes after induction (p < 0.05). The right-side RSO2 values were significantly lower at 3 and 5 minutes after induction in the propofol group compared to the ketofol group and the left-side RSO2 values were similarly significantly lower after 1, 3 and 5 minutes (p < 0.05). Ketofol used in anaesthesia induction has less effect than propofol on mean arterial pressure and cerebral oxygen saturation values. Therefore, ketofol appears to be a good choice for use in anaesthesia induction in elderly patients. [Med-Science 2020; 9(1.000): 21-5]http://www.ejmanager.com/fulltextpdf.php?mno=51082propofolketaminecerebral oximeterelderly patients |
| spellingShingle | Harun Tolga Duran Ersin Koksal Yasemin Burcu Ustun Sezgin Bilgin Fatih Ozkan The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age Medicine Science propofol ketamine cerebral oximeter elderly patients |
| title | The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| title_full | The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| title_fullStr | The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| title_full_unstemmed | The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| title_short | The effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| title_sort | effects of anaesthesia induction with propofol or ketofol on cerebral oxygenation in patients above 60 years of age |
| topic | propofol ketamine cerebral oximeter elderly patients |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=51082 |
| work_keys_str_mv | AT haruntolgaduran theeffectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT ersinkoksal theeffectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT yaseminburcuustun theeffectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT sezginbilgin theeffectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT fatihozkan theeffectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT haruntolgaduran effectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT ersinkoksal effectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT yaseminburcuustun effectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT sezginbilgin effectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage AT fatihozkan effectsofanaesthesiainductionwithpropofolorketofoloncerebraloxygenationinpatientsabove60yearsofage |