Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-04-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2020.00131/full |
| _version_ | 1818153587104022528 |
|---|---|
| author | Ellen Lowry Ellen Lowry Vaisakh Puthusseryppady Gillian Coughlan Stephen Jeffs Michael Hornberger |
| author_facet | Ellen Lowry Ellen Lowry Vaisakh Puthusseryppady Gillian Coughlan Stephen Jeffs Michael Hornberger |
| author_sort | Ellen Lowry |
| collection | DOAJ |
| description | Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributing factor to dementia and potentially AD. In particular, the sensitivity and specificity of path integration impairments in VCI compared to AD is unclear. In the current pilot study, we explore path integration performance in early-stage AD and VCI patient groups and hypothesize that: (i) medial parietal mediated egocentric processes will be more affected in VCI; and (ii) medial temporal mediated allocentric processes will be more affected in AD. This cross-sectional study included early-stage VCI patients (n = 9), AD patients (n = 10) and healthy age-matched controls (n = 20). All participants underwent extensive neuropsychological testing, as well as spatial navigation testing. The spatial navigation tests included the virtual reality “Supermarket” task assessing egocentric (body-based) and allocentric (map-based) navigation as well as the “Clock Orientation” test assessing egocentric and path integration processes. Results showed that egocentric integration processes are only impaired in VCI, potentially distinguishing it from AD. However, in contrast to our prediction, allocentric integration was not more impaired in AD compared to VCI. These preliminary findings suggest limited specificity of allocentric integration deficits between VCI and AD. By contrast, egocentric path integration deficits emerge as more specific to VCI, potentially allowing for more specific diagnostic and treatment outcome measures for vascular impairment in dementia. |
| first_indexed | 2024-12-11T14:12:59Z |
| format | Article |
| id | doaj.art-ba00d7e284fd4a4da4efec12c0d55897 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T14:12:59Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ba00d7e284fd4a4da4efec12c0d558972022-12-22T01:03:21ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-04-011410.3389/fnhum.2020.00131512929Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot StudyEllen Lowry0Ellen Lowry1Vaisakh Puthusseryppady2Gillian Coughlan3Stephen Jeffs4Michael Hornberger5Norwich Medical School, University of East Anglia, Norwich, United KingdomSchool of Psychology, University of East Anglia, Norwich, United KingdomNorwich Medical School, University of East Anglia, Norwich, United KingdomNorwich Medical School, University of East Anglia, Norwich, United KingdomNorwich Medical School, University of East Anglia, Norwich, United KingdomNorwich Medical School, University of East Anglia, Norwich, United KingdomPath integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite neurovascular change being a major contributing factor to dementia and potentially AD. In particular, the sensitivity and specificity of path integration impairments in VCI compared to AD is unclear. In the current pilot study, we explore path integration performance in early-stage AD and VCI patient groups and hypothesize that: (i) medial parietal mediated egocentric processes will be more affected in VCI; and (ii) medial temporal mediated allocentric processes will be more affected in AD. This cross-sectional study included early-stage VCI patients (n = 9), AD patients (n = 10) and healthy age-matched controls (n = 20). All participants underwent extensive neuropsychological testing, as well as spatial navigation testing. The spatial navigation tests included the virtual reality “Supermarket” task assessing egocentric (body-based) and allocentric (map-based) navigation as well as the “Clock Orientation” test assessing egocentric and path integration processes. Results showed that egocentric integration processes are only impaired in VCI, potentially distinguishing it from AD. However, in contrast to our prediction, allocentric integration was not more impaired in AD compared to VCI. These preliminary findings suggest limited specificity of allocentric integration deficits between VCI and AD. By contrast, egocentric path integration deficits emerge as more specific to VCI, potentially allowing for more specific diagnostic and treatment outcome measures for vascular impairment in dementia.https://www.frontiersin.org/article/10.3389/fnhum.2020.00131/fullnavigationegocentricvirtual-realitydementiaVCIvascular cognitive impairment |
| spellingShingle | Ellen Lowry Ellen Lowry Vaisakh Puthusseryppady Gillian Coughlan Stephen Jeffs Michael Hornberger Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study Frontiers in Human Neuroscience navigation egocentric virtual-reality dementia VCI vascular cognitive impairment |
| title | Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study |
| title_full | Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study |
| title_fullStr | Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study |
| title_full_unstemmed | Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study |
| title_short | Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study |
| title_sort | path integration changes as a cognitive marker for vascular cognitive impairment a pilot study |
| topic | navigation egocentric virtual-reality dementia VCI vascular cognitive impairment |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2020.00131/full |
| work_keys_str_mv | AT ellenlowry pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy AT ellenlowry pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy AT vaisakhputhusseryppady pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy AT gilliancoughlan pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy AT stephenjeffs pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy AT michaelhornberger pathintegrationchangesasacognitivemarkerforvascularcognitiveimpairmentapilotstudy |