Significance of CD47 expression in endometrial carcinoma
Objectives: CD47 is a membrane protein that belongs to the immunoglobulin superfamily and regulates macrophage phagocytosis negatively. As CD47 expression at the cancer cell membrane would inhibit the phagocytic activity of immune cells, it is connected to an unfavorable prognosis in leukemia and ma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=856;epage=859;aulast=Sahin |
| _version_ | 1797963522838102016 |
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| author | Nurhan Sahin Ganime Coban Nurcan Unver Dilek S Arici Gokhan Kilic Ozlem Toluk |
| author_facet | Nurhan Sahin Ganime Coban Nurcan Unver Dilek S Arici Gokhan Kilic Ozlem Toluk |
| author_sort | Nurhan Sahin |
| collection | DOAJ |
| description | Objectives: CD47 is a membrane protein that belongs to the immunoglobulin superfamily and regulates macrophage phagocytosis negatively. As CD47 expression at the cancer cell membrane would inhibit the phagocytic activity of immune cells, it is connected to an unfavorable prognosis in leukemia and malignancies of various solid organs. Materials and Methods: In this study, retrospectively evaluated 72 patients who had been diagnosed with endometrial carcinoma at Pathology Department and had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) and/or lymphadenectomy. CD47 expression was evaluated in tumorous and nontumor areas in all patients considering cytoplasmic and membranous brown staining in cells. The proportion of expression was evaluated as well as the intensity and an “h score” was obtained. This score was compared with known prognostic parameters. Results: CD47 expressions showed a statistically significant correlation with tumor grade (P < 0.05); however, no significant relationship was observed with myometrial invasion depth and lymph vascular invasion status (P = 0.923 and P = 0.754, respectively). Conclusions: As with other tumors, anti-CD47 antibody may be an alternative treatment option in patients with high-grade endometrial carcinoma. |
| first_indexed | 2024-04-11T01:29:41Z |
| format | Article |
| id | doaj.art-ba01c69a21cb4abfa0605f0fc7234b60 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-11T01:29:41Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-ba01c69a21cb4abfa0605f0fc7234b602023-01-03T09:56:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292022-01-0165485685910.4103/ijpm.ijpm_223_21Significance of CD47 expression in endometrial carcinomaNurhan SahinGanime CobanNurcan UnverDilek S AriciGokhan KilicOzlem TolukObjectives: CD47 is a membrane protein that belongs to the immunoglobulin superfamily and regulates macrophage phagocytosis negatively. As CD47 expression at the cancer cell membrane would inhibit the phagocytic activity of immune cells, it is connected to an unfavorable prognosis in leukemia and malignancies of various solid organs. Materials and Methods: In this study, retrospectively evaluated 72 patients who had been diagnosed with endometrial carcinoma at Pathology Department and had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) and/or lymphadenectomy. CD47 expression was evaluated in tumorous and nontumor areas in all patients considering cytoplasmic and membranous brown staining in cells. The proportion of expression was evaluated as well as the intensity and an “h score” was obtained. This score was compared with known prognostic parameters. Results: CD47 expressions showed a statistically significant correlation with tumor grade (P < 0.05); however, no significant relationship was observed with myometrial invasion depth and lymph vascular invasion status (P = 0.923 and P = 0.754, respectively). Conclusions: As with other tumors, anti-CD47 antibody may be an alternative treatment option in patients with high-grade endometrial carcinoma.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=856;epage=859;aulast=Sahincd47endometrial carcinomaimmunotherapymonoclonal antibody |
| spellingShingle | Nurhan Sahin Ganime Coban Nurcan Unver Dilek S Arici Gokhan Kilic Ozlem Toluk Significance of CD47 expression in endometrial carcinoma Indian Journal of Pathology and Microbiology cd47 endometrial carcinoma immunotherapy monoclonal antibody |
| title | Significance of CD47 expression in endometrial carcinoma |
| title_full | Significance of CD47 expression in endometrial carcinoma |
| title_fullStr | Significance of CD47 expression in endometrial carcinoma |
| title_full_unstemmed | Significance of CD47 expression in endometrial carcinoma |
| title_short | Significance of CD47 expression in endometrial carcinoma |
| title_sort | significance of cd47 expression in endometrial carcinoma |
| topic | cd47 endometrial carcinoma immunotherapy monoclonal antibody |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=856;epage=859;aulast=Sahin |
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