Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus
BackgroundDiabetic nephropathy is a leading cause of end-stage renal disease. The diagnostic markers of nephropathy, including the presence of albuminuria and/or a reduced estimated glomerular filtration rate, are not clinically ideal, and most of them are raised after a significant reduction in ren...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1124367/full |
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| author | Tadesse Asmamaw Dejenie Endeshaw Chekol Abebe Misganaw Asmamaw Mengstie Mohammed Abdu Seid Natnael Atnafu Gebeyehu Getachew Asmare Adella Gizchew Ambaw Kassie Amanuel Yosef Gebrekidan Molalegn Mesele Gesese Kirubel Dagnaw Tegegne Denekew Tenaw Anley Sefineh Fenta Feleke Melkamu Aderajew Zemene Anteneh Mengist Dessie Natnael Moges Yenealem Solomon Kebede Berihun Bantie Dagnew Getnet Adugna |
| author_facet | Tadesse Asmamaw Dejenie Endeshaw Chekol Abebe Misganaw Asmamaw Mengstie Mohammed Abdu Seid Natnael Atnafu Gebeyehu Getachew Asmare Adella Gizchew Ambaw Kassie Amanuel Yosef Gebrekidan Molalegn Mesele Gesese Kirubel Dagnaw Tegegne Denekew Tenaw Anley Sefineh Fenta Feleke Melkamu Aderajew Zemene Anteneh Mengist Dessie Natnael Moges Yenealem Solomon Kebede Berihun Bantie Dagnew Getnet Adugna |
| author_sort | Tadesse Asmamaw Dejenie |
| collection | DOAJ |
| description | BackgroundDiabetic nephropathy is a leading cause of end-stage renal disease. The diagnostic markers of nephropathy, including the presence of albuminuria and/or a reduced estimated glomerular filtration rate, are not clinically ideal, and most of them are raised after a significant reduction in renal function. Therefore, it is crucial to seek more sensitive and non-invasive biomarkers for the diagnosis of diabetic nephropathy.Objective of the studyThis study aimed to investigate the serum cystatin C levels and dyslipidemia for the detection of diabetic nephropathy in patients with type 2 diabetes mellitus.MethodologyA hospital-based comparative cross-sectional study was conducted from December 2021 to August 2022 in Tikur, Anbessa specialized teaching hospital with a sample size of 140 patients with type2 diabetes mellitus. Socio-demographic data was collected using a structured questionnaire, and 5 mL of blood was collected from each participant following overnight fasting for biochemical analyses.ResultsIn type 2 diabetes patients with nephropathy, we found significant lipoprotein abnormalities and an increase in serum cystatin C (P < 0.001) compared to those without nephropathy. Serum cystatin C, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, very low-density lipoprotein, high density lipoprotein, and duration of diabetes were identified as being significantly associated with diabetic nephropathy (P < 0.05) in multivariable logistic regression analysis. The mean values of total cholesterol levels, triglyceride levels, and high-density lipoprotein cholesterol levels were also found to be significantly higher (P < 0.05) in females as compared to male type-2 diabetic patients. The fasting blood glucose levels and lipid profiles of the participants were found to be significantly associated with serum cystatin C levels.ConclusionThe present study found significant serum cystatin C and lipoprotein abnormalities in T2DM patients with diabetic nephropathy when compared with those without diabetic nephropathy, and these lipoprotein abnormalities were significantly associated with serum cystatin C levels. |
| first_indexed | 2024-04-09T19:42:25Z |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T19:42:25Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ba02127a4e3b4eccb97324b7ecf94a862023-04-04T05:33:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11243671124367Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitusTadesse Asmamaw Dejenie0Endeshaw Chekol Abebe1Misganaw Asmamaw Mengstie2Mohammed Abdu Seid3Natnael Atnafu Gebeyehu4Getachew Asmare Adella5Gizchew Ambaw Kassie6Amanuel Yosef Gebrekidan7Molalegn Mesele Gesese8Kirubel Dagnaw Tegegne9Denekew Tenaw Anley10Sefineh Fenta Feleke11Melkamu Aderajew Zemene12Anteneh Mengist Dessie13Natnael Moges14Yenealem Solomon Kebede15Berihun Bantie16Dagnew Getnet Adugna17Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biochemistry, College of Health Science, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Physiology, College of Health Science, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, EthiopiaDepartment of Reproductive Health and Nutrition, School of Public Health, Woliata Sodo University, Sodo, EthiopiaDepartment of Epidemiology and Biostatistics, School of Public Health, Woliata Sodo University, Sodo, EthiopiaDepartment of Public Health, School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Sodo, EthiopiaDepartment of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, EthiopiaDepartment of Nursing, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia0Department of Public Health, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia1Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia2Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia3Department of Comprehensive Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia4Department of Anatomy, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, EthiopiaBackgroundDiabetic nephropathy is a leading cause of end-stage renal disease. The diagnostic markers of nephropathy, including the presence of albuminuria and/or a reduced estimated glomerular filtration rate, are not clinically ideal, and most of them are raised after a significant reduction in renal function. Therefore, it is crucial to seek more sensitive and non-invasive biomarkers for the diagnosis of diabetic nephropathy.Objective of the studyThis study aimed to investigate the serum cystatin C levels and dyslipidemia for the detection of diabetic nephropathy in patients with type 2 diabetes mellitus.MethodologyA hospital-based comparative cross-sectional study was conducted from December 2021 to August 2022 in Tikur, Anbessa specialized teaching hospital with a sample size of 140 patients with type2 diabetes mellitus. Socio-demographic data was collected using a structured questionnaire, and 5 mL of blood was collected from each participant following overnight fasting for biochemical analyses.ResultsIn type 2 diabetes patients with nephropathy, we found significant lipoprotein abnormalities and an increase in serum cystatin C (P < 0.001) compared to those without nephropathy. Serum cystatin C, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, very low-density lipoprotein, high density lipoprotein, and duration of diabetes were identified as being significantly associated with diabetic nephropathy (P < 0.05) in multivariable logistic regression analysis. The mean values of total cholesterol levels, triglyceride levels, and high-density lipoprotein cholesterol levels were also found to be significantly higher (P < 0.05) in females as compared to male type-2 diabetic patients. The fasting blood glucose levels and lipid profiles of the participants were found to be significantly associated with serum cystatin C levels.ConclusionThe present study found significant serum cystatin C and lipoprotein abnormalities in T2DM patients with diabetic nephropathy when compared with those without diabetic nephropathy, and these lipoprotein abnormalities were significantly associated with serum cystatin C levels.https://www.frontiersin.org/articles/10.3389/fendo.2023.1124367/fulldiabetesdiabetic nephropathyserum cystatin Cserum creatininedyslipidemia |
| spellingShingle | Tadesse Asmamaw Dejenie Endeshaw Chekol Abebe Misganaw Asmamaw Mengstie Mohammed Abdu Seid Natnael Atnafu Gebeyehu Getachew Asmare Adella Gizchew Ambaw Kassie Amanuel Yosef Gebrekidan Molalegn Mesele Gesese Kirubel Dagnaw Tegegne Denekew Tenaw Anley Sefineh Fenta Feleke Melkamu Aderajew Zemene Anteneh Mengist Dessie Natnael Moges Yenealem Solomon Kebede Berihun Bantie Dagnew Getnet Adugna Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus Frontiers in Endocrinology diabetes diabetic nephropathy serum cystatin C serum creatinine dyslipidemia |
| title | Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| title_full | Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| title_fullStr | Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| title_short | Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| title_sort | dyslipidemia and serum cystatin c levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus |
| topic | diabetes diabetic nephropathy serum cystatin C serum creatinine dyslipidemia |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1124367/full |
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