Studies on a novel regimen for management of orofacial pain and morphine tolerance
Background/purpose: The prevalence of orofacial pain is high but the etiology of orofacial pain is not well understood. Because of clinical treatment is not so effective, it is urgent to explore novel regimens with more effective and less side effects for clinical application. Materials and methods:...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Journal of Dental Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1991790217301307 |
| _version_ | 1798046339713466368 |
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| author | Yu-Hsien Lee Yu-Feng Huang Hsi-Hsien Chou Wen-Ting Lin Hui-Wen Yang Shoei-Yn Lin-Shiau |
| author_facet | Yu-Hsien Lee Yu-Feng Huang Hsi-Hsien Chou Wen-Ting Lin Hui-Wen Yang Shoei-Yn Lin-Shiau |
| author_sort | Yu-Hsien Lee |
| collection | DOAJ |
| description | Background/purpose: The prevalence of orofacial pain is high but the etiology of orofacial pain is not well understood. Because of clinical treatment is not so effective, it is urgent to explore novel regimens with more effective and less side effects for clinical application.
Materials and methods: Male mice (ICR strain) were injected with capsaicin (10μg/5 μl) in vibrissa pad. Spontaneous orofacial pain in 20 min was recorded after receiving capsaicin to quantify the nociceptive level. Green tea polyphenols (GTP 60 mg/kg), memantine (Mem 10 mg/kg), and GTPm (GTP 30 mg/kg plus Mem 3 mg/kg) were dissolved in 2% carboxymethyl cellulose, which was orally administered to mice twice per day and five times per week consecutively for 2 weeks. TruScan photobeam tracking was used to record changes of behavior and locomotor activities.
Results: GTPm by itself attenuated orofacial pain induced by capsaicin. Moreover, GTPm enhanced morphine analgesic effects, reduced morphine depressant side effects and delayed morphine tolerance. Along with this experiment, GTPm was tested on the hot plate (52 °C)-induced peripheral thermal pain. It was found that both memantine and GTPm reduced morphine-analgesia in hind paw thermal pain.
Conclusion: In this study, GTP (60 mg/kg/day) orally administrated produced a significant analgesic effect on capsaicin–induced orofacial pain. Memantine combined with GTP synergistically not only reduced orofacial pain but also enhanced morphine analgesic effects. Thus, a new regimen of GTPm orally administered twice per day attenuated orofacial pain after consecutive 5 days. |
| first_indexed | 2024-04-11T23:36:13Z |
| format | Article |
| id | doaj.art-ba024a90a84d42baa99070001111e732 |
| institution | Directory Open Access Journal |
| issn | 1991-7902 |
| language | English |
| last_indexed | 2024-04-11T23:36:13Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dental Sciences |
| spelling | doaj.art-ba024a90a84d42baa99070001111e7322022-12-22T03:56:57ZengElsevierJournal of Dental Sciences1991-79022018-06-0113213113710.1016/j.jds.2017.08.006Studies on a novel regimen for management of orofacial pain and morphine toleranceYu-Hsien Lee0Yu-Feng Huang1Hsi-Hsien Chou2Wen-Ting Lin3Hui-Wen Yang4Shoei-Yn Lin-Shiau5School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, TaiwanSchool of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, TaiwanBackground/purpose: The prevalence of orofacial pain is high but the etiology of orofacial pain is not well understood. Because of clinical treatment is not so effective, it is urgent to explore novel regimens with more effective and less side effects for clinical application. Materials and methods: Male mice (ICR strain) were injected with capsaicin (10μg/5 μl) in vibrissa pad. Spontaneous orofacial pain in 20 min was recorded after receiving capsaicin to quantify the nociceptive level. Green tea polyphenols (GTP 60 mg/kg), memantine (Mem 10 mg/kg), and GTPm (GTP 30 mg/kg plus Mem 3 mg/kg) were dissolved in 2% carboxymethyl cellulose, which was orally administered to mice twice per day and five times per week consecutively for 2 weeks. TruScan photobeam tracking was used to record changes of behavior and locomotor activities. Results: GTPm by itself attenuated orofacial pain induced by capsaicin. Moreover, GTPm enhanced morphine analgesic effects, reduced morphine depressant side effects and delayed morphine tolerance. Along with this experiment, GTPm was tested on the hot plate (52 °C)-induced peripheral thermal pain. It was found that both memantine and GTPm reduced morphine-analgesia in hind paw thermal pain. Conclusion: In this study, GTP (60 mg/kg/day) orally administrated produced a significant analgesic effect on capsaicin–induced orofacial pain. Memantine combined with GTP synergistically not only reduced orofacial pain but also enhanced morphine analgesic effects. Thus, a new regimen of GTPm orally administered twice per day attenuated orofacial pain after consecutive 5 days.http://www.sciencedirect.com/science/article/pii/S1991790217301307orofacial painmemantinegreen tea polyphenolN-methyl-d-asparate receptor |
| spellingShingle | Yu-Hsien Lee Yu-Feng Huang Hsi-Hsien Chou Wen-Ting Lin Hui-Wen Yang Shoei-Yn Lin-Shiau Studies on a novel regimen for management of orofacial pain and morphine tolerance Journal of Dental Sciences orofacial pain memantine green tea polyphenol N-methyl-d-asparate receptor |
| title | Studies on a novel regimen for management of orofacial pain and morphine tolerance |
| title_full | Studies on a novel regimen for management of orofacial pain and morphine tolerance |
| title_fullStr | Studies on a novel regimen for management of orofacial pain and morphine tolerance |
| title_full_unstemmed | Studies on a novel regimen for management of orofacial pain and morphine tolerance |
| title_short | Studies on a novel regimen for management of orofacial pain and morphine tolerance |
| title_sort | studies on a novel regimen for management of orofacial pain and morphine tolerance |
| topic | orofacial pain memantine green tea polyphenol N-methyl-d-asparate receptor |
| url | http://www.sciencedirect.com/science/article/pii/S1991790217301307 |
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