The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India
IntroductionAlthough excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed t...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1075448/full |
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| author | Summaiya Lari Summaiya Lari Praveen Yamagani Arun Pandiyan Janardhan Vanka Mohan Naidu Balakrishnan Senthil Kumar Babban Jee Padmaja R. Jonnalagadda |
| author_facet | Summaiya Lari Summaiya Lari Praveen Yamagani Arun Pandiyan Janardhan Vanka Mohan Naidu Balakrishnan Senthil Kumar Babban Jee Padmaja R. Jonnalagadda |
| author_sort | Summaiya Lari |
| collection | DOAJ |
| description | IntroductionAlthough excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed to assess the impact of the use of PPE on the minimization of effects of exposure to pesticides among farm-workers.MethodsA community-based follow-up study with questionnaire-based survey and field observations was undertaken among farm-workers (n = 180) of Rangareddy district, Telangana, India. Biomarkers of exposure such as cholinesterase activity, inflammatory markers (TNF-α, IL-1β, IL-6, cortisol, and hs-C reactive protein), nutrients (vitamins A, E), liver function (total protein and A/G ratio, AST and ALT levels) were investigated in the laboratory by following the standard protocols.ResultsFarm-workers who had a mean farming exposure of 18 years of and who neither followed safe pesticide handling practices nor used PPE and also showed reluctance to obey good agricultural practices (GAPs). Inhibition of AChE (acetylcholine esterase) with increased inflammation was found among farm-workers as compared to their respective normal values when they have not used PPE. Linear regression statistical analysis revealed a profound effect on inhibition in the AChE activity and various inflammatory markers with the increase in the duration of pesticide exposure. Further, there was no effect of the duration of pesticide exposure on the levels of vitamins A, E, ALT, AST, total protein, and A/G ratio. Further, intervention studies carried out on the use of PPE provided (commercially available and cost-effective) for 90 days showed a significant reduction in the biomarker levels (p < 0.01).ConclusionThis study demonstrated the importance of the use of PPE during pesticide applications and other agricultural tasks to minimize pesticide-associated adverse health effects. |
| first_indexed | 2024-04-09T23:22:11Z |
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| id | doaj.art-ba0363623d0a46c1bcf55d5413c6ef5b |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-09T23:22:11Z |
| publishDate | 2023-03-01 |
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| spelling | doaj.art-ba0363623d0a46c1bcf55d5413c6ef5b2023-03-21T14:39:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-03-011110.3389/fpubh.2023.10754481075448The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in IndiaSummaiya Lari0Summaiya Lari1Praveen Yamagani2Arun Pandiyan3Janardhan Vanka4Mohan Naidu5Balakrishnan Senthil Kumar6Babban Jee7Padmaja R. Jonnalagadda8ICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaDepartment of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaDepartment of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, IndiaICMR-National Institute of Nutrition, Hyderabad, Telangana, IndiaIntroductionAlthough excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed to assess the impact of the use of PPE on the minimization of effects of exposure to pesticides among farm-workers.MethodsA community-based follow-up study with questionnaire-based survey and field observations was undertaken among farm-workers (n = 180) of Rangareddy district, Telangana, India. Biomarkers of exposure such as cholinesterase activity, inflammatory markers (TNF-α, IL-1β, IL-6, cortisol, and hs-C reactive protein), nutrients (vitamins A, E), liver function (total protein and A/G ratio, AST and ALT levels) were investigated in the laboratory by following the standard protocols.ResultsFarm-workers who had a mean farming exposure of 18 years of and who neither followed safe pesticide handling practices nor used PPE and also showed reluctance to obey good agricultural practices (GAPs). Inhibition of AChE (acetylcholine esterase) with increased inflammation was found among farm-workers as compared to their respective normal values when they have not used PPE. Linear regression statistical analysis revealed a profound effect on inhibition in the AChE activity and various inflammatory markers with the increase in the duration of pesticide exposure. Further, there was no effect of the duration of pesticide exposure on the levels of vitamins A, E, ALT, AST, total protein, and A/G ratio. Further, intervention studies carried out on the use of PPE provided (commercially available and cost-effective) for 90 days showed a significant reduction in the biomarker levels (p < 0.01).ConclusionThis study demonstrated the importance of the use of PPE during pesticide applications and other agricultural tasks to minimize pesticide-associated adverse health effects.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1075448/fullpesticidesfarm-workersoccupational exposurepersonal-protective-equipmentrisk assessmentcholinesterase |
| spellingShingle | Summaiya Lari Summaiya Lari Praveen Yamagani Arun Pandiyan Janardhan Vanka Mohan Naidu Balakrishnan Senthil Kumar Babban Jee Padmaja R. Jonnalagadda The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India Frontiers in Public Health pesticides farm-workers occupational exposure personal-protective-equipment risk assessment cholinesterase |
| title | The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India |
| title_full | The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India |
| title_fullStr | The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India |
| title_full_unstemmed | The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India |
| title_short | The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India |
| title_sort | impact of the use of personal protective equipment on the minimization of effects of exposure to pesticides among farm workers in india |
| topic | pesticides farm-workers occupational exposure personal-protective-equipment risk assessment cholinesterase |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1075448/full |
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