Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women
Abstract This study was performed to evaluate quality of life (QOL) and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women with low bone mass. This multicenter, prospective, noninterventional observational study included 3907 postmenopausal women who rec...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11298-2 |
| _version_ | 1829114558479859712 |
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| author | Dong-Yun Lee Yoon-Sok Chung |
| author_facet | Dong-Yun Lee Yoon-Sok Chung |
| author_sort | Dong-Yun Lee |
| collection | DOAJ |
| description | Abstract This study was performed to evaluate quality of life (QOL) and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women with low bone mass. This multicenter, prospective, noninterventional observational study included 3907 postmenopausal women who received a combination of raloxifene 60 mg and cholecalciferol 800 IU daily to treat or prevent osteoporosis. Changes in QOL and patient satisfaction were evaluated after 3 and 6 months of treatment. In addition, the safety profile was assessed. Mean age was 67.7 ± 9.3 years old. QOL, assessed by European Quality of life instrument 5 Dimensions (EQ-5D) index, improved significantly after 3 months (0.81 ± 0.11, P < 0.001) and 6 months (0.82 ± 0.11, P < 0.001) of treatment compared to the baseline (0.78 ± 0.14). Improvement in QOL was also significant regardless of previous regimens both in women who were switched from other drugs (bisphosphonates or selective estrogen receptor modulators) and in women who received the study drug for the first time (P < 0.001 for all comparisons). Percentage of women satisfied with the effects (from 37.3 to 67.7%, P < 0.001) and convenience (from 42.8 to 74.1%, P < 0.001) of treatment compared to previous medication significantly increased after 6 months of treatment. In addition, serious adverse drug reactions did not occur, and hot flushes were observed only in 12 women (0.3%). Combination therapy with raloxifene and cholecalciferol significantly improves quality of life with no serious adverse events and high patient satisfaction at 6 months. Our real-world data suggest that this regimen is a promising option for postmenopausal women with low bone mass. |
| first_indexed | 2024-12-12T15:56:18Z |
| format | Article |
| id | doaj.art-ba048d19b8174ae9814fb52c51429c35 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T15:56:18Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ba048d19b8174ae9814fb52c51429c352022-12-22T00:19:29ZengNature PortfolioScientific Reports2045-23222022-05-011211810.1038/s41598-022-11298-2Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal womenDong-Yun Lee0Yoon-Sok Chung1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Endocrinology and Metabolism, Ajou University School of MedicineAbstract This study was performed to evaluate quality of life (QOL) and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women with low bone mass. This multicenter, prospective, noninterventional observational study included 3907 postmenopausal women who received a combination of raloxifene 60 mg and cholecalciferol 800 IU daily to treat or prevent osteoporosis. Changes in QOL and patient satisfaction were evaluated after 3 and 6 months of treatment. In addition, the safety profile was assessed. Mean age was 67.7 ± 9.3 years old. QOL, assessed by European Quality of life instrument 5 Dimensions (EQ-5D) index, improved significantly after 3 months (0.81 ± 0.11, P < 0.001) and 6 months (0.82 ± 0.11, P < 0.001) of treatment compared to the baseline (0.78 ± 0.14). Improvement in QOL was also significant regardless of previous regimens both in women who were switched from other drugs (bisphosphonates or selective estrogen receptor modulators) and in women who received the study drug for the first time (P < 0.001 for all comparisons). Percentage of women satisfied with the effects (from 37.3 to 67.7%, P < 0.001) and convenience (from 42.8 to 74.1%, P < 0.001) of treatment compared to previous medication significantly increased after 6 months of treatment. In addition, serious adverse drug reactions did not occur, and hot flushes were observed only in 12 women (0.3%). Combination therapy with raloxifene and cholecalciferol significantly improves quality of life with no serious adverse events and high patient satisfaction at 6 months. Our real-world data suggest that this regimen is a promising option for postmenopausal women with low bone mass.https://doi.org/10.1038/s41598-022-11298-2 |
| spellingShingle | Dong-Yun Lee Yoon-Sok Chung Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women Scientific Reports |
| title | Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women |
| title_full | Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women |
| title_fullStr | Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women |
| title_full_unstemmed | Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women |
| title_short | Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women |
| title_sort | quality of life and patient satisfaction with raloxifene cholecalciferol combination therapy in postmenopausal women |
| url | https://doi.org/10.1038/s41598-022-11298-2 |
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