Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial

Abstract Background HIV self-testing (HIVST), especially the secondary distribution of HIVST (SD-HIVST) initiated by sexual health influencers (SHIs), has been recognized as an effective strategy in promoting HIV testing, especially among men who have sex with men (MSM). This quasi-experimental stud...

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Main Authors: Ying Lu, Yuxin Ni, Qianyun Wang, Fengshi Jing, Yi Zhou, Xi He, Shanzi Huang, Wencan Dai, Dan Wu, Joseph D. Tucker, Hongbo Jiang, Liqun Huang, Weiming Tang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Public Health
Subjects:
Online Access:https://doi.org/10.1186/s12889-021-11817-2
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author Ying Lu
Yuxin Ni
Qianyun Wang
Fengshi Jing
Yi Zhou
Xi He
Shanzi Huang
Wencan Dai
Dan Wu
Joseph D. Tucker
Hongbo Jiang
Liqun Huang
Weiming Tang
author_facet Ying Lu
Yuxin Ni
Qianyun Wang
Fengshi Jing
Yi Zhou
Xi He
Shanzi Huang
Wencan Dai
Dan Wu
Joseph D. Tucker
Hongbo Jiang
Liqun Huang
Weiming Tang
author_sort Ying Lu
collection DOAJ
description Abstract Background HIV self-testing (HIVST), especially the secondary distribution of HIVST (SD-HIVST) initiated by sexual health influencers (SHIs), has been recognized as an effective strategy in promoting HIV testing, especially among men who have sex with men (MSM). This quasi-experimental study aimed to evaluate whether SHIs identified through the ensemble machine learning approach can distribute more HIVST than those who identified by the empiricalscale. Methods We will recruit eligible adults (≥18 years old) who were assigned male gender at birth, and willing to participate in potential SD-HIVST online. Participants will be assigned randomly to two groups (scale group or machine learning group), followed by a separate process of SHI identification based on the group assignment. After identification, all index participants (defined as identified SHIs who are verbally consented to participate in SD-HIVST or who directly order HIVST kits) will follow the same procedure for SD-HIVST acquisition and distribution. Index participants can order HIVST online and distribute them to members within their social networks (defined as alters) in-person or virtually through a personalized peer referral link. Once a unique alter uploads a photographed test result to the platform, both the alter and the corresponding index participant will receive a fixed incentive of 3 USD. The index MSM can order up to five HIVST in the first three months and ten HIVST in the following three months. Each index participant will need to complete a baseline survey at the first-time ordering and one to two follow-upbased on the times of ordering,, three months after ordering. This trial will be comparing 1) the mean number of alters motivated by each index participant in each group and 2) the mean number of newly-tested alters motivated by each index participant in each group. Discussion In promoting the efficacy of identifying SHIs for SD-HIVST, our study has the potential to enhance testing coverage, particularly among marginalized individuals and those who are reluctant to for HIV and other sexually transmitted infections. Trial registration We registered the study on the Chinese Clinical Trial Registry website on 4th November 2021, with registration number ChiCTR2000039632 .
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spelling doaj.art-ba0492d88be04af995675702232b39e82022-12-21T19:30:12ZengBMCBMC Public Health1471-24582021-09-012111910.1186/s12889-021-11817-2Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trialYing Lu0Yuxin Ni1Qianyun Wang2Fengshi Jing3Yi Zhou4Xi He5Shanzi Huang6Wencan Dai7Dan Wu8Joseph D. Tucker9Hongbo Jiang10Liqun Huang11Weiming Tang12Dermatology Hospital of South Medical UniversityDermatology Hospital of South Medical UniversityDermatology Hospital of South Medical UniversityInstitute for Healthcare Artificial Intelligence, Guangdong Second Provincial General HospitalZhuhai Center for Diseases Control and PreventionZhuhai Xutong Voluntary Services CenterZhuhai Center for Diseases Control and PreventionZhuhai Center for Diseases Control and PreventionUniversity of North Carolina Project-ChinaUniversity of North Carolina Project-ChinaGuangdong Pharmaceutical UniversityZhuhai Center for Diseases Control and PreventionDermatology Hospital of South Medical UniversityAbstract Background HIV self-testing (HIVST), especially the secondary distribution of HIVST (SD-HIVST) initiated by sexual health influencers (SHIs), has been recognized as an effective strategy in promoting HIV testing, especially among men who have sex with men (MSM). This quasi-experimental study aimed to evaluate whether SHIs identified through the ensemble machine learning approach can distribute more HIVST than those who identified by the empiricalscale. Methods We will recruit eligible adults (≥18 years old) who were assigned male gender at birth, and willing to participate in potential SD-HIVST online. Participants will be assigned randomly to two groups (scale group or machine learning group), followed by a separate process of SHI identification based on the group assignment. After identification, all index participants (defined as identified SHIs who are verbally consented to participate in SD-HIVST or who directly order HIVST kits) will follow the same procedure for SD-HIVST acquisition and distribution. Index participants can order HIVST online and distribute them to members within their social networks (defined as alters) in-person or virtually through a personalized peer referral link. Once a unique alter uploads a photographed test result to the platform, both the alter and the corresponding index participant will receive a fixed incentive of 3 USD. The index MSM can order up to five HIVST in the first three months and ten HIVST in the following three months. Each index participant will need to complete a baseline survey at the first-time ordering and one to two follow-upbased on the times of ordering,, three months after ordering. This trial will be comparing 1) the mean number of alters motivated by each index participant in each group and 2) the mean number of newly-tested alters motivated by each index participant in each group. Discussion In promoting the efficacy of identifying SHIs for SD-HIVST, our study has the potential to enhance testing coverage, particularly among marginalized individuals and those who are reluctant to for HIV and other sexually transmitted infections. Trial registration We registered the study on the Chinese Clinical Trial Registry website on 4th November 2021, with registration number ChiCTR2000039632 .https://doi.org/10.1186/s12889-021-11817-2Sexual health influencersEnsemble machine learningSecondary distributionHIV self-testingMen who have sex with menChina
spellingShingle Ying Lu
Yuxin Ni
Qianyun Wang
Fengshi Jing
Yi Zhou
Xi He
Shanzi Huang
Wencan Dai
Dan Wu
Joseph D. Tucker
Hongbo Jiang
Liqun Huang
Weiming Tang
Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
BMC Public Health
Sexual health influencers
Ensemble machine learning
Secondary distribution
HIV self-testing
Men who have sex with men
China
title Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
title_full Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
title_fullStr Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
title_full_unstemmed Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
title_short Effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a quasi-experimental trial
title_sort effectiveness of sexual health influencers identified by an ensemble machine learning model in promoting secondary distribution of hiv self testing among men who have sex with men in china study protocol for a quasi experimental trial
topic Sexual health influencers
Ensemble machine learning
Secondary distribution
HIV self-testing
Men who have sex with men
China
url https://doi.org/10.1186/s12889-021-11817-2
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