Effects of nigella sativa oil on allergic rhinitis: an experimental animal study
Objectives: Nigella sativa oil is known antiallergic and immunomodulatory effects. We aimed to compare this oil with mometasone furoate, a topical steroid, on a rat model in the prevention of allergic rhinitis symptoms. Methods: A total of 28 two-to-four-month-old Wistar Hannover rats weighing 250–3...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869422001185 |
| _version_ | 1828090652249817088 |
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| author | Recep Gul Hasan Deniz Tansuker Abdurrahman Bugra Cengiz Melda Gul Alper Tabaru Funda Emre Mehmet Faruk Oktay |
| author_facet | Recep Gul Hasan Deniz Tansuker Abdurrahman Bugra Cengiz Melda Gul Alper Tabaru Funda Emre Mehmet Faruk Oktay |
| author_sort | Recep Gul |
| collection | DOAJ |
| description | Objectives: Nigella sativa oil is known antiallergic and immunomodulatory effects. We aimed to compare this oil with mometasone furoate, a topical steroid, on a rat model in the prevention of allergic rhinitis symptoms. Methods: A total of 28 two-to-four-month-old Wistar Hannover rats weighing 250–350 g were randomly divided into four groups of seven, which included control, allergic rhinitis, mometasone furoate, and Nigella sativa oil groups. Loss of cilia, an increase of goblet cells, vascular proliferation, inflammatory cell count, eosinophil infiltration, and the degree of hypertrophy in chondrocytes were assessed by light microscopy. Results: The frequency of nasal scratching in the Nigella sativa oil group was found to be significantly lower compared with the allergic rhinitis group (p < 0.05). Typical inflammatory changes seen in allergic rhinitis were not detected in the Nigella sativa oil group. No inflammation was observed in 85.7% of both the healthy control group and the Nigella sativa oil group. In addition, no inflammation was observed in 71.4% of the mometasone furoate group, and this difference was found to be significant compared with the control group (p < 0.05). In addition, eosinophil infiltration, cilia loss, chondrocyte hypertrophy, vascular proliferation, and goblet cell increase were found to be significantly decreased in the mometazone furoate and Nigella sativa oil groups compared to the allergic rhinitis group (p < 0.05). Conclusion: According to the findings obtained from this study, we found anti-inflammatory and anti-allergic effects of Nigella sativa oil as equally effective as mometasone furoate in the treatment of experimentaly generated allergic rhinitis. Level of evidence: IV. |
| first_indexed | 2024-04-11T06:01:12Z |
| format | Article |
| id | doaj.art-ba057ce10de9488380c626a24b576a7f |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-04-11T06:01:12Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-ba057ce10de9488380c626a24b576a7f2022-12-22T04:41:42ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942022-11-0188S148S155Effects of nigella sativa oil on allergic rhinitis: an experimental animal studyRecep Gul0Hasan Deniz Tansuker1Abdurrahman Bugra Cengiz2Melda Gul3Alper Tabaru4Funda Emre5Mehmet Faruk Oktay6University of Health Sciences Kanuni Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, TurkeyYeditepe University, Faculty of Medicine, Department of Otorhinolaryngology, Istanbul, TurkeyUniversity of Health Sciences Bagcilar Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey; Corresponding author.Mehmet Akif Cardiovascular and Thorasic Surgery Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, TurkeyBasaksehir Cam and Sakura State Hospital, Department of Otorhinolaryngology, Istanbul, TurkeyUniversity of Health Sciences Bagcilar Training and Research Hospital, Department of Pathology, Istanbul, TurkeyUniversity of Health Sciences Bagcilar Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, TurkeyObjectives: Nigella sativa oil is known antiallergic and immunomodulatory effects. We aimed to compare this oil with mometasone furoate, a topical steroid, on a rat model in the prevention of allergic rhinitis symptoms. Methods: A total of 28 two-to-four-month-old Wistar Hannover rats weighing 250–350 g were randomly divided into four groups of seven, which included control, allergic rhinitis, mometasone furoate, and Nigella sativa oil groups. Loss of cilia, an increase of goblet cells, vascular proliferation, inflammatory cell count, eosinophil infiltration, and the degree of hypertrophy in chondrocytes were assessed by light microscopy. Results: The frequency of nasal scratching in the Nigella sativa oil group was found to be significantly lower compared with the allergic rhinitis group (p < 0.05). Typical inflammatory changes seen in allergic rhinitis were not detected in the Nigella sativa oil group. No inflammation was observed in 85.7% of both the healthy control group and the Nigella sativa oil group. In addition, no inflammation was observed in 71.4% of the mometasone furoate group, and this difference was found to be significant compared with the control group (p < 0.05). In addition, eosinophil infiltration, cilia loss, chondrocyte hypertrophy, vascular proliferation, and goblet cell increase were found to be significantly decreased in the mometazone furoate and Nigella sativa oil groups compared to the allergic rhinitis group (p < 0.05). Conclusion: According to the findings obtained from this study, we found anti-inflammatory and anti-allergic effects of Nigella sativa oil as equally effective as mometasone furoate in the treatment of experimentaly generated allergic rhinitis. Level of evidence: IV.http://www.sciencedirect.com/science/article/pii/S1808869422001185Allergic rhinitisMometasone furoateNigella sativa oil |
| spellingShingle | Recep Gul Hasan Deniz Tansuker Abdurrahman Bugra Cengiz Melda Gul Alper Tabaru Funda Emre Mehmet Faruk Oktay Effects of nigella sativa oil on allergic rhinitis: an experimental animal study Brazilian Journal of Otorhinolaryngology Allergic rhinitis Mometasone furoate Nigella sativa oil |
| title | Effects of nigella sativa oil on allergic rhinitis: an experimental animal study |
| title_full | Effects of nigella sativa oil on allergic rhinitis: an experimental animal study |
| title_fullStr | Effects of nigella sativa oil on allergic rhinitis: an experimental animal study |
| title_full_unstemmed | Effects of nigella sativa oil on allergic rhinitis: an experimental animal study |
| title_short | Effects of nigella sativa oil on allergic rhinitis: an experimental animal study |
| title_sort | effects of nigella sativa oil on allergic rhinitis an experimental animal study |
| topic | Allergic rhinitis Mometasone furoate Nigella sativa oil |
| url | http://www.sciencedirect.com/science/article/pii/S1808869422001185 |
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