Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress
Autism spectrum disorder (ASD) is becoming one of the fastest growing neurodevelopmen-tal disorders around the world, yet its clinical treatment still faces challenge due to the heterogeneity in etiology and symptom phenotypes. It is believed that excitatory-inhibitory (E-I) imbalance in the central...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Medical Journal of Peking Union Medical College Hospital
2023-07-01
|
| Series: | Xiehe Yixue Zazhi |
| Subjects: | |
| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0174 |
| _version_ | 1797761331613401088 |
|---|---|
| author | SHI Yue ZHU Bo HUANG Yuguang |
| author_facet | SHI Yue ZHU Bo HUANG Yuguang |
| author_sort | SHI Yue |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is becoming one of the fastest growing neurodevelopmen-tal disorders around the world, yet its clinical treatment still faces challenge due to the heterogeneity in etiology and symptom phenotypes. It is believed that excitatory-inhibitory (E-I) imbalance in the central nervous system may play an important role in the pathogenic mechanisms of ASD. E-I imbalances in synaptic transmission and neural circuits are frequently observed in different animal models of ASD, and the corresponding reversion normalizes the autism-like behaviors in these animals. Some E-I modulators have been tested for their therapeutic potential on ASD patients with encouraging results. This article expounds the mechanism of E-I imbalance in ASD and E-I imbalance regulators treatment progress, to provide new insights on the therapeutic targets for ASD. |
| first_indexed | 2024-03-12T19:11:26Z |
| format | Article |
| id | doaj.art-ba07307d52dc4822aec3a891d97770a6 |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-03-12T19:11:26Z |
| publishDate | 2023-07-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-ba07307d52dc4822aec3a891d97770a62023-08-02T05:52:24ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812023-07-0114484484910.12290/xhyxzz.2023-0174Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment ProgressSHI YueZHU BoHUANG YuguangAutism spectrum disorder (ASD) is becoming one of the fastest growing neurodevelopmen-tal disorders around the world, yet its clinical treatment still faces challenge due to the heterogeneity in etiology and symptom phenotypes. It is believed that excitatory-inhibitory (E-I) imbalance in the central nervous system may play an important role in the pathogenic mechanisms of ASD. E-I imbalances in synaptic transmission and neural circuits are frequently observed in different animal models of ASD, and the corresponding reversion normalizes the autism-like behaviors in these animals. Some E-I modulators have been tested for their therapeutic potential on ASD patients with encouraging results. This article expounds the mechanism of E-I imbalance in ASD and E-I imbalance regulators treatment progress, to provide new insights on the therapeutic targets for ASD.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0174autism spectrum disorderexcitatory-inhibitory imbalanceanimal modelselectrophysiology |
| spellingShingle | SHI Yue ZHU Bo HUANG Yuguang Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress Xiehe Yixue Zazhi autism spectrum disorder excitatory-inhibitory imbalance animal models electrophysiology |
| title | Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress |
| title_full | Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress |
| title_fullStr | Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress |
| title_full_unstemmed | Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress |
| title_short | Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress |
| title_sort | excitatory inhibitory imbalance and autism spectrum disorder mechanism and treatment progress |
| topic | autism spectrum disorder excitatory-inhibitory imbalance animal models electrophysiology |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0174 |
| work_keys_str_mv | AT shiyue excitatoryinhibitoryimbalanceandautismspectrumdisordermechanismandtreatmentprogress AT zhubo excitatoryinhibitoryimbalanceandautismspectrumdisordermechanismandtreatmentprogress AT huangyuguang excitatoryinhibitoryimbalanceandautismspectrumdisordermechanismandtreatmentprogress |