A malaria merozoite surface protein (MSP1)-structure, processing and function
Merozoite surface protein-1 (MSP-1, also referred to as P195, PMMSA or MSA 1) is one of the most studied of all malaria proteins. The proteins. The protein is found in all malaria species investigated and structural studies on the gene indicate that parts of the molecule are well-conserved. Studies...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1992-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700004 |
| _version_ | 1797713440229294080 |
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| author | Anthony A. Holder Michael J. Blackman Petra A. Burghaus Jonathan A. Chappel Irene T. Ling Neil McCallum-Deighton Shafrira Shai |
| author_facet | Anthony A. Holder Michael J. Blackman Petra A. Burghaus Jonathan A. Chappel Irene T. Ling Neil McCallum-Deighton Shafrira Shai |
| author_sort | Anthony A. Holder |
| collection | DOAJ |
| description | Merozoite surface protein-1 (MSP-1, also referred to as P195, PMMSA or MSA 1) is one of the most studied of all malaria proteins. The proteins. The protein is found in all malaria species investigated and structural studies on the gene indicate that parts of the molecule are well-conserved. Studies on Plasmodium falciparum have shown that the protein is in a processed form on the merozoite surface, a result of proteolytic cleavage of the large percursor molecule. Recent studies have identified some of these cleavage sites. During invasion of the new red cell most of the MSP1 molecule is shed from the parasite surface except for a small C-terminal fragment which can be detected in ring stages. Analysis of the structure of this fragment suggests that it contains two growth factor-like domains that may have a functional role. |
| first_indexed | 2024-03-12T07:36:37Z |
| format | Article |
| id | doaj.art-ba07b479315b47e4958f20f0f3c68c7f |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:36:37Z |
| publishDate | 1992-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-ba07b479315b47e4958f20f0f3c68c7f2023-09-02T21:28:50ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601992-01-0187374210.1590/S0074-02761992000700004A malaria merozoite surface protein (MSP1)-structure, processing and functionAnthony A. HolderMichael J. BlackmanPetra A. BurghausJonathan A. ChappelIrene T. LingNeil McCallum-DeightonShafrira ShaiMerozoite surface protein-1 (MSP-1, also referred to as P195, PMMSA or MSA 1) is one of the most studied of all malaria proteins. The proteins. The protein is found in all malaria species investigated and structural studies on the gene indicate that parts of the molecule are well-conserved. Studies on Plasmodium falciparum have shown that the protein is in a processed form on the merozoite surface, a result of proteolytic cleavage of the large percursor molecule. Recent studies have identified some of these cleavage sites. During invasion of the new red cell most of the MSP1 molecule is shed from the parasite surface except for a small C-terminal fragment which can be detected in ring stages. Analysis of the structure of this fragment suggests that it contains two growth factor-like domains that may have a functional role.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700004malariamerozoite surface proteinPlasmodium |
| spellingShingle | Anthony A. Holder Michael J. Blackman Petra A. Burghaus Jonathan A. Chappel Irene T. Ling Neil McCallum-Deighton Shafrira Shai A malaria merozoite surface protein (MSP1)-structure, processing and function Memorias do Instituto Oswaldo Cruz malaria merozoite surface protein Plasmodium |
| title | A malaria merozoite surface protein (MSP1)-structure, processing and function |
| title_full | A malaria merozoite surface protein (MSP1)-structure, processing and function |
| title_fullStr | A malaria merozoite surface protein (MSP1)-structure, processing and function |
| title_full_unstemmed | A malaria merozoite surface protein (MSP1)-structure, processing and function |
| title_short | A malaria merozoite surface protein (MSP1)-structure, processing and function |
| title_sort | malaria merozoite surface protein msp1 structure processing and function |
| topic | malaria merozoite surface protein Plasmodium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700004 |
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