Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.
Subarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore no...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0253219 |
| _version_ | 1818460567073980416 |
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| author | Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang |
| author_facet | Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang |
| author_sort | Pengcheng Zhao |
| collection | DOAJ |
| description | Subarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore normal blood flow, and prevent vasospasm. Treatment for SAH varies, depending on the bleeding's underlying cause and the extent of damage to the brain. Treatment may include lifesaving measures, symptom relief, repair of the bleeding vessel, and complication prevention. However, the useful diagnostic biomarkers of SAH are still limited due to the instability of gene marker expression. To overcome this limitation, we developed a new protocol pairing genes and screened significant gene pairs based on the feature selection algorithm. A classifier was constructed with the selected gene pairs and achieved a high performance. |
| first_indexed | 2024-12-14T23:32:18Z |
| format | Article |
| id | doaj.art-ba07e5a3fb234db6b0b99f5df507a34d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T23:32:18Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ba07e5a3fb234db6b0b99f5df507a34d2022-12-21T22:43:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01166e025321910.1371/journal.pone.0253219Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm.Pengcheng ZhaoShaonian XuZhenshan HuangPengcheng DengYongming ZhangSubarachnoid hemorrhage (SAH) is a fatal stroke caused by bleeding in the brain. SAH can be caused by a ruptured aneurysm or head injury. One-third of patients will survive and recover. One-third will survive with disability; one-third will die. The focus of treatment is to stop bleeding, restore normal blood flow, and prevent vasospasm. Treatment for SAH varies, depending on the bleeding's underlying cause and the extent of damage to the brain. Treatment may include lifesaving measures, symptom relief, repair of the bleeding vessel, and complication prevention. However, the useful diagnostic biomarkers of SAH are still limited due to the instability of gene marker expression. To overcome this limitation, we developed a new protocol pairing genes and screened significant gene pairs based on the feature selection algorithm. A classifier was constructed with the selected gene pairs and achieved a high performance.https://doi.org/10.1371/journal.pone.0253219 |
| spellingShingle | Pengcheng Zhao Shaonian Xu Zhenshan Huang Pengcheng Deng Yongming Zhang Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. PLoS ONE |
| title | Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. |
| title_full | Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. |
| title_fullStr | Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. |
| title_full_unstemmed | Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. |
| title_short | Identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm. |
| title_sort | identify specific gene pairs for subarachnoid hemorrhage based on wavelet analysis and genetic algorithm |
| url | https://doi.org/10.1371/journal.pone.0253219 |
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