SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells
SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com br...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2020-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/58374 |
| _version_ | 1811180559519449088 |
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| author | Erik Oliemuller Richard Newman Siu Man Tsang Shane Foo Gareth Muirhead Farzana Noor Syed Haider Iskander Aurrekoetxea-Rodríguez Maria dM Vivanco Beatrice A Howard |
| author_facet | Erik Oliemuller Richard Newman Siu Man Tsang Shane Foo Gareth Muirhead Farzana Noor Syed Haider Iskander Aurrekoetxea-Rodríguez Maria dM Vivanco Beatrice A Howard |
| author_sort | Erik Oliemuller |
| collection | DOAJ |
| description | SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybrid epithelial/mesenchymal cells, which display invasive features and alterations in metastatic tropism when xenografted into mice. We found that SOX11+DCIS tumour cells metastasize to brain and bone at greater frequency and to lungs at lower frequency compared to cells with lower SOX11 levels. High levels of SOX11 leads to the expression of markers associated with mesenchymal state and embryonic cellular phenotypes. Our results suggest that SOX11 may be a potential biomarker for breast tumours with elevated risk of developing metastases and may require more aggressive therapies. |
| first_indexed | 2024-04-11T09:05:21Z |
| format | Article |
| id | doaj.art-ba0899cdda394041938c14f10c71925f |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:21Z |
| publishDate | 2020-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ba0899cdda394041938c14f10c71925f2022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2020-09-01910.7554/eLife.58374SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cellsErik Oliemuller0https://orcid.org/0000-0002-4506-0504Richard Newman1Siu Man Tsang2Shane Foo3Gareth Muirhead4Farzana Noor5Syed Haider6Iskander Aurrekoetxea-Rodríguez7Maria dM Vivanco8Beatrice A Howard9https://orcid.org/0000-0002-9162-0314The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomTranslational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United KingdomThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, SpainCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, SpainThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United KingdomSOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com breast cancer cells, leading to populations enriched with highly plastic hybrid epithelial/mesenchymal cells, which display invasive features and alterations in metastatic tropism when xenografted into mice. We found that SOX11+DCIS tumour cells metastasize to brain and bone at greater frequency and to lungs at lower frequency compared to cells with lower SOX11 levels. High levels of SOX11 leads to the expression of markers associated with mesenchymal state and embryonic cellular phenotypes. Our results suggest that SOX11 may be a potential biomarker for breast tumours with elevated risk of developing metastases and may require more aggressive therapies.https://elifesciences.org/articles/58374SOX11DCISbreast cancerMEX3A |
| spellingShingle | Erik Oliemuller Richard Newman Siu Man Tsang Shane Foo Gareth Muirhead Farzana Noor Syed Haider Iskander Aurrekoetxea-Rodríguez Maria dM Vivanco Beatrice A Howard SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells eLife SOX11 DCIS breast cancer MEX3A |
| title | SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| title_full | SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| title_fullStr | SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| title_full_unstemmed | SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| title_short | SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| title_sort | sox11 promotes epithelial mesenchymal hybrid state and alters tropism of invasive breast cancer cells |
| topic | SOX11 DCIS breast cancer MEX3A |
| url | https://elifesciences.org/articles/58374 |
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