SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. Here, we show that SOX11 confers distinct features to ER-negative DCIS.com br...

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Bibliographic Details
Main Authors: Erik Oliemuller, Richard Newman, Siu Man Tsang, Shane Foo, Gareth Muirhead, Farzana Noor, Syed Haider, Iskander Aurrekoetxea-Rodríguez, Maria dM Vivanco, Beatrice A Howard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
SOX11
DCIS
breast cancer
MEX3A
Online Access:https://elifesciences.org/articles/58374

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