Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study
The need to maintain body lean as cats age is shown in both health and disease. In healthy cats, body lean is associated with enhanced movement and overall longevity. In many disease states (i.e., renal disease, obesity), an enhanced or minimally maximal support of body lean is associated with quali...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/4/299 |
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| author | Kiran S. Panickar Mary C. DeBey Dennis E. Jewell |
| author_facet | Kiran S. Panickar Mary C. DeBey Dennis E. Jewell |
| author_sort | Kiran S. Panickar |
| collection | DOAJ |
| description | The need to maintain body lean as cats age is shown in both health and disease. In healthy cats, body lean is associated with enhanced movement and overall longevity. In many disease states (i.e., renal disease, obesity), an enhanced or minimally maximal support of body lean is associated with quality of life and is a nutritional goal in aiding in the management of the disease. This study was designed to investigate the effect of these two dietary components and their combination on body composition and circulating factors of health, including metabolomics analysis and cytokine concentration. The foods that were fed for 169 days to four groups of cats and consisted of control food (formulated to meet the nutritional needs of all adult cats), carnitine-enhanced food (control food plus 300 mg/kg L-carnitine), carnosine-enhanced food (control food plus 1000 mg/kg carnosine), and food enhanced with both (control plus 300 mg/kg carnitine and 1000 mg/kg carnosine). Dietary enhancement with L-carnitine and carnosine increased body lean at the end of the study compared to the cats consuming the control food or the combination food. The cats consuming L-carnitine alone had a decreased concentration of circulating cytokines, while those consuming the combination food had an increased concentration of glucose, pyruvate, succinate, and circulating cytokines. |
| first_indexed | 2024-03-10T12:36:04Z |
| format | Article |
| id | doaj.art-ba092d8eef5a45ac977d9057ccc29a56 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T12:36:04Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-ba092d8eef5a45ac977d9057ccc29a562023-11-21T14:16:09ZengMDPI AGBiology2079-77372021-04-0110429910.3390/biology10040299Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary StudyKiran S. Panickar0Mary C. DeBey1Dennis E. Jewell2Hill’s Pet Nutrition Inc., Topeka, KS 66617, USAHill’s Pet Nutrition Inc., Topeka, KS 66617, USADepartment of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USAThe need to maintain body lean as cats age is shown in both health and disease. In healthy cats, body lean is associated with enhanced movement and overall longevity. In many disease states (i.e., renal disease, obesity), an enhanced or minimally maximal support of body lean is associated with quality of life and is a nutritional goal in aiding in the management of the disease. This study was designed to investigate the effect of these two dietary components and their combination on body composition and circulating factors of health, including metabolomics analysis and cytokine concentration. The foods that were fed for 169 days to four groups of cats and consisted of control food (formulated to meet the nutritional needs of all adult cats), carnitine-enhanced food (control food plus 300 mg/kg L-carnitine), carnosine-enhanced food (control food plus 1000 mg/kg carnosine), and food enhanced with both (control plus 300 mg/kg carnitine and 1000 mg/kg carnosine). Dietary enhancement with L-carnitine and carnosine increased body lean at the end of the study compared to the cats consuming the control food or the combination food. The cats consuming L-carnitine alone had a decreased concentration of circulating cytokines, while those consuming the combination food had an increased concentration of glucose, pyruvate, succinate, and circulating cytokines.https://www.mdpi.com/2079-7737/10/4/299carnitinecarnosinebody leanmetabolomicscytokines |
| spellingShingle | Kiran S. Panickar Mary C. DeBey Dennis E. Jewell Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study Biology carnitine carnosine body lean metabolomics cytokines |
| title | Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study |
| title_full | Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study |
| title_fullStr | Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study |
| title_full_unstemmed | Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study |
| title_short | Dietary Carnitine and Carnosine Increase Body Lean in Healthy Cats in a Preliminary Study |
| title_sort | dietary carnitine and carnosine increase body lean in healthy cats in a preliminary study |
| topic | carnitine carnosine body lean metabolomics cytokines |
| url | https://www.mdpi.com/2079-7737/10/4/299 |
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