Untangling Alzheimer’s disease with spatial multi-omics: a brief review
Alzheimer’s disease (AD) is the most common form of neurological dementia, specified by extracellular β-amyloid plaque deposition, neurofibrillary tangles, and cognitive impairment. AD-associated pathologies like cerebral amyloid angiopathy (CAA) are also affiliated with cognitive impairment and hav...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1150512/full |
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| author | Cody R. Marshall Cody R. Marshall Melissa A. Farrow Melissa A. Farrow Katerina V. Djambazova Katerina V. Djambazova Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins |
| author_facet | Cody R. Marshall Cody R. Marshall Melissa A. Farrow Melissa A. Farrow Katerina V. Djambazova Katerina V. Djambazova Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins |
| author_sort | Cody R. Marshall |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common form of neurological dementia, specified by extracellular β-amyloid plaque deposition, neurofibrillary tangles, and cognitive impairment. AD-associated pathologies like cerebral amyloid angiopathy (CAA) are also affiliated with cognitive impairment and have overlapping molecular drivers, including amyloid buildup. Discerning the complexity of these neurological disorders remains a significant challenge, and the spatiomolecular relationships between pathogenic features of AD and AD-associated pathologies remain poorly understood. This review highlights recent developments in spatial omics, including profiling and molecular imaging methods, and how they are applied to AD. These emerging technologies aim to characterize the relationship between how specific cell types and tissue features are organized in combination with mapping molecular distributions to provide a systems biology view of the tissue microenvironment around these neuropathologies. As spatial omics methods achieve greater resolution and improved molecular coverage, they are enabling deeper characterization of the molecular drivers of AD, leading to new possibilities for the prediction, diagnosis, and mitigation of this debilitating disease. |
| first_indexed | 2024-03-12T23:12:46Z |
| format | Article |
| id | doaj.art-ba09651be18f4ca2ae9a096431e12fcc |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T23:12:46Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ba09651be18f4ca2ae9a096431e12fcc2023-07-17T23:25:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-07-011510.3389/fnagi.2023.11505121150512Untangling Alzheimer’s disease with spatial multi-omics: a brief reviewCody R. Marshall0Cody R. Marshall1Melissa A. Farrow2Melissa A. Farrow3Katerina V. Djambazova4Katerina V. Djambazova5Jeffrey M. Spraggins6Jeffrey M. Spraggins7Jeffrey M. Spraggins8Jeffrey M. Spraggins9Jeffrey M. Spraggins10Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, TN, United StatesMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, United StatesMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United StatesMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, United StatesChemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, TN, United StatesMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Chemistry, Vanderbilt University, Nashville, TN, United StatesAlzheimer’s disease (AD) is the most common form of neurological dementia, specified by extracellular β-amyloid plaque deposition, neurofibrillary tangles, and cognitive impairment. AD-associated pathologies like cerebral amyloid angiopathy (CAA) are also affiliated with cognitive impairment and have overlapping molecular drivers, including amyloid buildup. Discerning the complexity of these neurological disorders remains a significant challenge, and the spatiomolecular relationships between pathogenic features of AD and AD-associated pathologies remain poorly understood. This review highlights recent developments in spatial omics, including profiling and molecular imaging methods, and how they are applied to AD. These emerging technologies aim to characterize the relationship between how specific cell types and tissue features are organized in combination with mapping molecular distributions to provide a systems biology view of the tissue microenvironment around these neuropathologies. As spatial omics methods achieve greater resolution and improved molecular coverage, they are enabling deeper characterization of the molecular drivers of AD, leading to new possibilities for the prediction, diagnosis, and mitigation of this debilitating disease.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1150512/fullAlzheimer’s diseasespatial multi-omicsmass spectrometryneuroscienceimaging mass spectrometry (IMS)spatial transcriptomics (ST) |
| spellingShingle | Cody R. Marshall Cody R. Marshall Melissa A. Farrow Melissa A. Farrow Katerina V. Djambazova Katerina V. Djambazova Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Jeffrey M. Spraggins Untangling Alzheimer’s disease with spatial multi-omics: a brief review Frontiers in Aging Neuroscience Alzheimer’s disease spatial multi-omics mass spectrometry neuroscience imaging mass spectrometry (IMS) spatial transcriptomics (ST) |
| title | Untangling Alzheimer’s disease with spatial multi-omics: a brief review |
| title_full | Untangling Alzheimer’s disease with spatial multi-omics: a brief review |
| title_fullStr | Untangling Alzheimer’s disease with spatial multi-omics: a brief review |
| title_full_unstemmed | Untangling Alzheimer’s disease with spatial multi-omics: a brief review |
| title_short | Untangling Alzheimer’s disease with spatial multi-omics: a brief review |
| title_sort | untangling alzheimer s disease with spatial multi omics a brief review |
| topic | Alzheimer’s disease spatial multi-omics mass spectrometry neuroscience imaging mass spectrometry (IMS) spatial transcriptomics (ST) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1150512/full |
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