Resistant starch and type 2 diabetes mellitus: Clinical perspective
Abstract The immediate and well‐documented benefits of carbohydrate restriction include improved glycemic control in individuals with diabetes mellitus. Starch, a significant source of carbohydrates, is categorized as rapidly digestible, slowly digestible, or resistant starch (RS). RS, which is a no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.14139 |
| _version_ | 1827572354459369472 |
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| author | Min Kyung Kim Juri Park Doo‐Man Kim |
| author_facet | Min Kyung Kim Juri Park Doo‐Man Kim |
| author_sort | Min Kyung Kim |
| collection | DOAJ |
| description | Abstract The immediate and well‐documented benefits of carbohydrate restriction include improved glycemic control in individuals with diabetes mellitus. Starch, a significant source of carbohydrates, is categorized as rapidly digestible, slowly digestible, or resistant starch (RS). RS, which is a non‐viscous fermentable fiber, has shown promise in animal studies for antidiabetic effects by improving glucose metabolism. Although the exact mechanism by which RS affects glucose metabolism remains unclear, it is expected to positively impact glucose tolerance and insulin sensitivity. The fermentation of RS by colonic microbiota in the large bowel produces short‐chain fatty acids, which exert multiple metabolic effects on glucose regulation and homeostasis. Moreover, RS may influence glucose metabolism via bile acid modulation, independent of its fermentation. Diets rich in RS could aid in blood glucose homeostasis. However, it is uncertain whether they can alter the metabolic pathology associated with glucose regulation. In essence, RS has the potential to lower postprandial glucose levels similarly to a low‐glycemic index diet. Yet, its efficacy as a medical nutrition therapy for type 2 diabetes needs further investigation. To confirm the role of RS in glycemic control and to possibly recommend it as an additional dietary approach for people with type 2 diabetes mellitus, a well‐designed, large‐scale intervention is required. |
| first_indexed | 2024-04-24T16:28:32Z |
| format | Article |
| id | doaj.art-ba098ae7c9744fe28021ab08d79a989e |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-24T16:28:32Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-ba098ae7c9744fe28021ab08d79a989e2024-03-30T10:00:09ZengWileyJournal of Diabetes Investigation2040-11162040-11242024-04-0115439540110.1111/jdi.14139Resistant starch and type 2 diabetes mellitus: Clinical perspectiveMin Kyung Kim0Juri Park1Doo‐Man Kim2Department of Internal Medicine, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul South KoreaDepartment of Internal Medicine Shihwa Medical Center Shihwa South KoreaDepartment of Internal Medicine, Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul South KoreaAbstract The immediate and well‐documented benefits of carbohydrate restriction include improved glycemic control in individuals with diabetes mellitus. Starch, a significant source of carbohydrates, is categorized as rapidly digestible, slowly digestible, or resistant starch (RS). RS, which is a non‐viscous fermentable fiber, has shown promise in animal studies for antidiabetic effects by improving glucose metabolism. Although the exact mechanism by which RS affects glucose metabolism remains unclear, it is expected to positively impact glucose tolerance and insulin sensitivity. The fermentation of RS by colonic microbiota in the large bowel produces short‐chain fatty acids, which exert multiple metabolic effects on glucose regulation and homeostasis. Moreover, RS may influence glucose metabolism via bile acid modulation, independent of its fermentation. Diets rich in RS could aid in blood glucose homeostasis. However, it is uncertain whether they can alter the metabolic pathology associated with glucose regulation. In essence, RS has the potential to lower postprandial glucose levels similarly to a low‐glycemic index diet. Yet, its efficacy as a medical nutrition therapy for type 2 diabetes needs further investigation. To confirm the role of RS in glycemic control and to possibly recommend it as an additional dietary approach for people with type 2 diabetes mellitus, a well‐designed, large‐scale intervention is required.https://doi.org/10.1111/jdi.14139Diabetes mellitus, type 2DietResistant starch |
| spellingShingle | Min Kyung Kim Juri Park Doo‐Man Kim Resistant starch and type 2 diabetes mellitus: Clinical perspective Journal of Diabetes Investigation Diabetes mellitus, type 2 Diet Resistant starch |
| title | Resistant starch and type 2 diabetes mellitus: Clinical perspective |
| title_full | Resistant starch and type 2 diabetes mellitus: Clinical perspective |
| title_fullStr | Resistant starch and type 2 diabetes mellitus: Clinical perspective |
| title_full_unstemmed | Resistant starch and type 2 diabetes mellitus: Clinical perspective |
| title_short | Resistant starch and type 2 diabetes mellitus: Clinical perspective |
| title_sort | resistant starch and type 2 diabetes mellitus clinical perspective |
| topic | Diabetes mellitus, type 2 Diet Resistant starch |
| url | https://doi.org/10.1111/jdi.14139 |
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