New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i>
Five new cyclic diarylheptanoids (platycary A–E, compounds <b>1</b>–<b>5</b>) and three previously identified analogues (i.e., phttyearynol (compound <b>6</b>), myricatomentogenin (compound <b>7</b>), and juglanin D (compound <b>8</b>)) wer...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/24/6034 |
| _version_ | 1797544091876065280 |
|---|---|
| author | Wen-bing Ding Rui-yuan Zhao Guan-hua Li Bing-lei Liu Hua-liang He Lin Qiu Jin Xue You-zhi Li |
| author_facet | Wen-bing Ding Rui-yuan Zhao Guan-hua Li Bing-lei Liu Hua-liang He Lin Qiu Jin Xue You-zhi Li |
| author_sort | Wen-bing Ding |
| collection | DOAJ |
| description | Five new cyclic diarylheptanoids (platycary A–E, compounds <b>1</b>–<b>5</b>) and three previously identified analogues (i.e., phttyearynol (compound <b>6</b>), myricatomentogenin (compound <b>7</b>), and juglanin D (compound <b>8</b>)) were isolated from the stem bark of <i>Platycarya strobilacea</i>. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds <b>1</b>–<b>5</b> and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds <b>1</b> and <b>2</b> significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ. |
| first_indexed | 2024-03-10T13:54:32Z |
| format | Article |
| id | doaj.art-ba09c9247e2540119858d21846004ab6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:54:32Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ba09c9247e2540119858d21846004ab62023-11-21T01:44:39ZengMDPI AGMolecules1420-30492020-12-012524603410.3390/molecules25246034New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i>Wen-bing Ding0Rui-yuan Zhao1Guan-hua Li2Bing-lei Liu3Hua-liang He4Lin Qiu5Jin Xue6You-zhi Li7Hunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, ChinaHunnan Cotton Science Institute, Changde 415100, ChinaNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaHunnan Cotton Science Institute, Changde 415100, ChinaNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaNational Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, ChinaHunan Provincial Engineering and Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, ChinaFive new cyclic diarylheptanoids (platycary A–E, compounds <b>1</b>–<b>5</b>) and three previously identified analogues (i.e., phttyearynol (compound <b>6</b>), myricatomentogenin (compound <b>7</b>), and juglanin D (compound <b>8</b>)) were isolated from the stem bark of <i>Platycarya strobilacea</i>. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds <b>1</b>–<b>5</b> and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds <b>1</b> and <b>2</b> significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ.https://www.mdpi.com/1420-3049/25/24/6034cyclic diarylheptanoid<i>Platycarya strobilacea</i>Juglandaceaecorticosterone-induced apoptosis |
| spellingShingle | Wen-bing Ding Rui-yuan Zhao Guan-hua Li Bing-lei Liu Hua-liang He Lin Qiu Jin Xue You-zhi Li New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> Molecules cyclic diarylheptanoid <i>Platycarya strobilacea</i> Juglandaceae corticosterone-induced apoptosis |
| title | New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> |
| title_full | New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> |
| title_fullStr | New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> |
| title_full_unstemmed | New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> |
| title_short | New Cyclic Diarylheptanoids from <i>Platycarya strobilacea</i> |
| title_sort | new cyclic diarylheptanoids from i platycarya strobilacea i |
| topic | cyclic diarylheptanoid <i>Platycarya strobilacea</i> Juglandaceae corticosterone-induced apoptosis |
| url | https://www.mdpi.com/1420-3049/25/24/6034 |
| work_keys_str_mv | AT wenbingding newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT ruiyuanzhao newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT guanhuali newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT bingleiliu newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT hualianghe newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT linqiu newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT jinxue newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai AT youzhili newcyclicdiarylheptanoidsfromiplatycaryastrobilaceai |