Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage

Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage

Cutaneous melanoma, a lethal skin cancer, arises from malignant transformation of melanocytes. Solar ultraviolet radiation (UVR) is a major environmental risk factor for melanoma since its interaction with the skin generates DNA damage, either directly or indirectly via oxidative stress. Pheomelanin...

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Bibliographic Details
Main Authors: María Castejón-Griñán, Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Cecilia Herraiz, Celia Jiménez-Cervantes, José Carlos García-Borrón
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Redox Biology
Subjects:
Melanocortin 1 receptor (MC1R)
Oxidative DNA damage
Melanoma
Reactive oxygen species (ROS)
Base excision repair (BER)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001113

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http://www.sciencedirect.com/science/article/pii/S2213231724001113

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