Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. In recent years, the incidence rate has been increasing. Mitochondria are dynamic organelles involved in various cell behaviors in eukaryotic cells. Mitochondrial dysfunction is closely related to tumor development...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2022-03-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.03.009 |
| _version_ | 1798021095563984896 |
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| author | TANG Xiaoyi ZHANG Pan WANG Kaiyan NIU Lina JIAO Kai XIAO Yuhong |
| author_facet | TANG Xiaoyi ZHANG Pan WANG Kaiyan NIU Lina JIAO Kai XIAO Yuhong |
| author_sort | TANG Xiaoyi |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. In recent years, the incidence rate has been increasing. Mitochondria are dynamic organelles involved in various cell behaviors in eukaryotic cells. Mitochondrial dysfunction is closely related to tumor development. As a switch that determines cancer cell death, targeting mitochondria has become the focus of OSCC treatment. This article reviews the relationship between mitochondria and tumorigenesis and development, OSCC treatment, and cisplatin resistant OSCC. Current studies have found that mitochondrial dysfunction promotes cell carcinogenesis, and the mitochondrial morphology and function of cancer cells are significantly changed. The increase of mitochondrial fission improves the invasiveness of cancer cells, and mitophagy dysfunction can induce cancer cell apoptosis. The emergence of drugs and the development of nanotechnology in targeted drug delivery systems have opened up new methods for targeting mitochondria to treat OSCC, reducing the side effects of systemic medication. The cisplatin resistance of OSCC is generated through the mitochondrial pathway, and the mitochondrial function and mutation mechanism of mitochondrial DNA are clarified in order to provide new ideas for targeting mitochondria to treat cisplatin resistant OSCC. |
| first_indexed | 2024-04-11T17:08:29Z |
| format | Article |
| id | doaj.art-ba0b153cd78b4b8aa5e56b06ec9079cb |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-11T17:08:29Z |
| publishDate | 2022-03-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-ba0b153cd78b4b8aa5e56b06ec9079cb2022-12-22T04:12:58ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562022-03-0130321221610.12016/j.issn.2096-1456.2022.03.009Research progress on the relationship between mitochondrial function and oral squamous cell carcinomaTANG Xiaoyi0 ZHANG Pan1WANG Kaiyan2NIU Lina3JIAO Kai4XIAO Yuhong5 Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force/Kunming Medical University Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force/Kunming Medical University State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, the Fourth Military Medical University State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Oral Mucosa, School of Stomatology, the Fourth Military Medical University Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force/Kunming Medical UniversityOral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. In recent years, the incidence rate has been increasing. Mitochondria are dynamic organelles involved in various cell behaviors in eukaryotic cells. Mitochondrial dysfunction is closely related to tumor development. As a switch that determines cancer cell death, targeting mitochondria has become the focus of OSCC treatment. This article reviews the relationship between mitochondria and tumorigenesis and development, OSCC treatment, and cisplatin resistant OSCC. Current studies have found that mitochondrial dysfunction promotes cell carcinogenesis, and the mitochondrial morphology and function of cancer cells are significantly changed. The increase of mitochondrial fission improves the invasiveness of cancer cells, and mitophagy dysfunction can induce cancer cell apoptosis. The emergence of drugs and the development of nanotechnology in targeted drug delivery systems have opened up new methods for targeting mitochondria to treat OSCC, reducing the side effects of systemic medication. The cisplatin resistance of OSCC is generated through the mitochondrial pathway, and the mitochondrial function and mutation mechanism of mitochondrial DNA are clarified in order to provide new ideas for targeting mitochondria to treat cisplatin resistant OSCC.http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.03.009oral squamous cell carcinoma，tumor，mitochondria，mitochondrial dna，mitochondrial dysfunction，mitophagy，cell apoptosis，cisplatin resistance， |
| spellingShingle | TANG Xiaoyi ZHANG Pan WANG Kaiyan NIU Lina JIAO Kai XIAO Yuhong Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma 口腔疾病防治 oral squamous cell carcinoma， tumor， mitochondria， mitochondrial dna， mitochondrial dysfunction， mitophagy， cell apoptosis， cisplatin resistance， |
| title | Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| title_full | Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| title_fullStr | Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| title_full_unstemmed | Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| title_short | Research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| title_sort | research progress on the relationship between mitochondrial function and oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma， tumor， mitochondria， mitochondrial dna， mitochondrial dysfunction， mitophagy， cell apoptosis， cisplatin resistance， |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.03.009 |
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