Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer
Although a dysfunctional gut microbiome is strongly linked to colorectal cancer (CRC), our knowledge of the mediators between CRC and the microbiome is limited. MicroRNAs (miRNAs) affect critical cellular processes, such as apoptosis, proliferation, and differentiation, and contribute to the regulat...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.804689/full |
| _version_ | 1818255918561755136 |
|---|---|
| author | Juan Xing Yiqun Liao Huan Zhang Wenjie Zhang Zhilin Zhang Jie Zhang Daorong Wang Dong Tang |
| author_facet | Juan Xing Yiqun Liao Huan Zhang Wenjie Zhang Zhilin Zhang Jie Zhang Daorong Wang Dong Tang |
| author_sort | Juan Xing |
| collection | DOAJ |
| description | Although a dysfunctional gut microbiome is strongly linked to colorectal cancer (CRC), our knowledge of the mediators between CRC and the microbiome is limited. MicroRNAs (miRNAs) affect critical cellular processes, such as apoptosis, proliferation, and differentiation, and contribute to the regulation of CRC progression. Increasingly, studies found that miRNAs can significantly mediate bidirectional interactions between the host and the microbiome. Notably, miRNA expression is regulated by the gut microbiome, which subsequently affects the host transcriptome, thereby influencing the development of CRC. This study typically focuses on the specific functions of the microbiome in CRC and their effect on CRC-related miRNA production and reviews the role of several bacteria on miRNA, including Fusobacterium nucleatum, Escherichia coli, enterotoxigenic Bacteroides fragilis, and Faecalibacterium prausnitzii. Based on the important roles of miRNAs and the gut microbiome in CRC, strategies for modulating miRNA expression and regulating the gut microbiome composition need to be applied, such as bioactive dietary components and fecal microorganism transplantation. |
| first_indexed | 2024-12-12T17:19:30Z |
| format | Article |
| id | doaj.art-ba0cdc063ae84caf88d369df1101c1c6 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-12T17:19:30Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-ba0cdc063ae84caf88d369df1101c1c62022-12-22T00:17:42ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-04-011210.3389/fcimb.2022.804689804689Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal CancerJuan Xing0Yiqun Liao1Huan Zhang2Wenjie Zhang3Zhilin Zhang4Jie Zhang5Daorong Wang6Dong Tang7Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of Clinical Medical College, Dalian Medical University, Dalian, ChinaClinical Medical College, Yangzhou University, Yangzhou, ChinaClinical Medical College, Yangzhou University, Yangzhou, ChinaClinical Medical College, Yangzhou University, Yangzhou, ChinaClinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Yangzhou University, Yangzhou, ChinaAlthough a dysfunctional gut microbiome is strongly linked to colorectal cancer (CRC), our knowledge of the mediators between CRC and the microbiome is limited. MicroRNAs (miRNAs) affect critical cellular processes, such as apoptosis, proliferation, and differentiation, and contribute to the regulation of CRC progression. Increasingly, studies found that miRNAs can significantly mediate bidirectional interactions between the host and the microbiome. Notably, miRNA expression is regulated by the gut microbiome, which subsequently affects the host transcriptome, thereby influencing the development of CRC. This study typically focuses on the specific functions of the microbiome in CRC and their effect on CRC-related miRNA production and reviews the role of several bacteria on miRNA, including Fusobacterium nucleatum, Escherichia coli, enterotoxigenic Bacteroides fragilis, and Faecalibacterium prausnitzii. Based on the important roles of miRNAs and the gut microbiome in CRC, strategies for modulating miRNA expression and regulating the gut microbiome composition need to be applied, such as bioactive dietary components and fecal microorganism transplantation.https://www.frontiersin.org/articles/10.3389/fcimb.2022.804689/fullcolorectal cancermicroRNAsgut microbiomebioactive dietary componentsmodulation |
| spellingShingle | Juan Xing Yiqun Liao Huan Zhang Wenjie Zhang Zhilin Zhang Jie Zhang Daorong Wang Dong Tang Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer Frontiers in Cellular and Infection Microbiology colorectal cancer microRNAs gut microbiome bioactive dietary components modulation |
| title | Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_full | Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_fullStr | Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_full_unstemmed | Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_short | Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_sort | impacts of micrornas induced by the gut microbiome on regulating the development of colorectal cancer |
| topic | colorectal cancer microRNAs gut microbiome bioactive dietary components modulation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.804689/full |
| work_keys_str_mv | AT juanxing impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT yiqunliao impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT huanzhang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT wenjiezhang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT zhilinzhang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT jiezhang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT daorongwang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer AT dongtang impactsofmicrornasinducedbythegutmicrobiomeonregulatingthedevelopmentofcolorectalcancer |