Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis
The objective: to determine factors influencing treatment efficacy in patients with multiple (MDR) and extensive (XDR) drug resistant tuberculosis. Subjects and methods. The medical files of 107 tuberculosis patients (men – 75, women – 32) were analyzed, 17 of them were HIV positive. Those 107 patie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-11-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1471 |
| _version_ | 1797696705352695808 |
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| author | I. S. Lapshina B. U. Salikhov T. V. Myakisheva S. V. Kostromtsov A. V. Paramonov V. A. Аndreev |
| author_facet | I. S. Lapshina B. U. Salikhov T. V. Myakisheva S. V. Kostromtsov A. V. Paramonov V. A. Аndreev |
| author_sort | I. S. Lapshina |
| collection | DOAJ |
| description | The objective: to determine factors influencing treatment efficacy in patients with multiple (MDR) and extensive (XDR) drug resistant tuberculosis. Subjects and methods. The medical files of 107 tuberculosis patients (men – 75, women – 32) were analyzed, 17 of them were HIV positive. Those 107 patients were registered for treatment as per chemotherapy (CT) regimens IV-V in 2017 in Kaluga Region. 99 (92.5%) patients suffered from tuberculosis with lung tissue destruction. 60.7% (65 patients) had MDR, while 20.8% (22 patients) had XDR. Only 58.2% of patients had MDR TB confirmed by polymerase chain reaction before treatment start.Results. In 24 months, the effective course of treatment was registered in 64/107 (59.8%). The highest level of effective treatment was expectedly registered among new cases – 21/30 (70%); and the lowest level was among patients starting chemotherapy again after treatment interruption – 4/10 (40%), p > 0.05. Among 64 patients with effective treatment course, 25 (39.1%) had surgery and 39 (60.9%) had chemotherapy only. Surgical activity among the cohort of 2017 made 26/107 (24.3%). The effective treatment outcome was achieved in 8 (47%) out of 17 patients with TB/HIV co-infection, and among HIV negative patients it was reached in 56/90 (62.2%), p > 0,05. |
| first_indexed | 2024-03-12T03:30:10Z |
| format | Article |
| id | doaj.art-ba0f249af49f473da9c2d01c15536bb4 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T03:30:10Z |
| publishDate | 2020-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-ba0f249af49f473da9c2d01c15536bb42023-09-03T13:29:07ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-11-019810283210.21292/2075-1230-2020-98-10-28-321469Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosisI. S. Lapshina0B. U. Salikhov1T. V. Myakisheva2S. V. Kostromtsov3A. V. Paramonov4V. A. Аndreev5ГБУЗ Калужской области «Областная клиническая туберкулезная больница»ГБУЗ Калужской области «Областная клиническая туберкулезная больница»ФГБОУ «Смоленский государственный медицинский университет» МЗ РФГБУЗ Калужской области «Областная клиническая туберкулезная больница»ГБУЗ Калужской области «Областная клиническая туберкулезная больница»ГБУЗ Калужской области «Областная клиническая туберкулезная больница»The objective: to determine factors influencing treatment efficacy in patients with multiple (MDR) and extensive (XDR) drug resistant tuberculosis. Subjects and methods. The medical files of 107 tuberculosis patients (men – 75, women – 32) were analyzed, 17 of them were HIV positive. Those 107 patients were registered for treatment as per chemotherapy (CT) regimens IV-V in 2017 in Kaluga Region. 99 (92.5%) patients suffered from tuberculosis with lung tissue destruction. 60.7% (65 patients) had MDR, while 20.8% (22 patients) had XDR. Only 58.2% of patients had MDR TB confirmed by polymerase chain reaction before treatment start.Results. In 24 months, the effective course of treatment was registered in 64/107 (59.8%). The highest level of effective treatment was expectedly registered among new cases – 21/30 (70%); and the lowest level was among patients starting chemotherapy again after treatment interruption – 4/10 (40%), p > 0.05. Among 64 patients with effective treatment course, 25 (39.1%) had surgery and 39 (60.9%) had chemotherapy only. Surgical activity among the cohort of 2017 made 26/107 (24.3%). The effective treatment outcome was achieved in 8 (47%) out of 17 patients with TB/HIV co-infection, and among HIV negative patients it was reached in 56/90 (62.2%), p > 0,05.https://www.tibl-journal.com/jour/article/view/1471туберкулезмножественная/широкая лекарственная устойчивостьхирургическое лечениетуберкулез и вич-инфекция |
| spellingShingle | I. S. Lapshina B. U. Salikhov T. V. Myakisheva S. V. Kostromtsov A. V. Paramonov V. A. Аndreev Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis Туберкулез и болезни лёгких туберкулез множественная/широкая лекарственная устойчивость хирургическое лечение туберкулез и вич-инфекция |
| title | Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| title_full | Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| title_fullStr | Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| title_full_unstemmed | Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| title_short | Factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| title_sort | factors influencing treatment efficacy in patients with multiple and extensive drug resistant tuberculosis |
| topic | туберкулез множественная/широкая лекарственная устойчивость хирургическое лечение туберкулез и вич-инфекция |
| url | https://www.tibl-journal.com/jour/article/view/1471 |
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