Maternal separation and TNBS-induced gut inflammation synergistically alter the sexually differentiated stress response in rats

Maternal separation and TNBS-induced gut inflammation synergistically alter the sexually differentiated stress response in rats

Abstract Background Neonatal maternal separation (MS) has been used to model long-lasting changes in behavior caused by neuroplastic changes associated with exposure to early-life stress. Earlier studies showed that transient gut inflammation can influence the development of irritable bowel syndrome...

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Bibliographic Details
Main Authors: Ryoko Hasegawa, Kumi Saito-Nakaya, Li Gu, Motoyori Kanazawa, Shin Fukudo
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BioPsychoSocial Medicine
Subjects:
Attention-deficit/hyperactivity disorder
Corticotropin-releasing hormone
Early-life stress
Irritable bowel syndrome
Maternal separation
Visceral hypersensitivity
Online Access:https://doi.org/10.1186/s13030-022-00258-x

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