Development of QSAR models for in silico screening of antibody solubility

Although monoclonal antibodies (mAbs) have been shown to be extremely effective in treating a number of diseases, they often suffer from poor developability attributes, such as high viscosity and low solubility at elevated concentrations. Since experimental candidate screening is often materials and...

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Bibliographic Details
Main Authors: Xuan Han, James Shih, Yuhao Lin, Qing Chai, Steven M. Cramer
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2062807