Drug-induced oral ulcerations: case report
A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency,...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2016-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/243158 |
| _version_ | 1797207966794907648 |
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| author | Vanja Vučičević Boras Snježana Židovec-Lepej Branka Marinović Sven Seiwerth Ivana Škrinjar Dražen Pulanić Danica Vidović Juras |
| author_facet | Vanja Vučičević Boras Snježana Židovec-Lepej Branka Marinović Sven Seiwerth Ivana Škrinjar Dražen Pulanić Danica Vidović Juras |
| author_sort | Vanja Vučičević Boras |
| collection | DOAJ |
| description | A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers. One of the possible explanations was that the lesions were due to the use of drugs, the more so as oral lesions evolved when the doses of allopurinol and chlorambucil were increased, and subsided when the doses of both drugs were decreased. However, we could not establish
for sure whether the lesions were due to allopurinol or chlorambucil. According to literature data, allopurinol is one of the most frequent drugs known to induce skin adverse reactions, therefore we assumed that it was the culprit drug. Unfortunately, several weeks later the patient died from sepsis, pneumonia with respiratory insufficiency and multiorgan failure. |
| first_indexed | 2024-04-24T09:31:19Z |
| format | Article |
| id | doaj.art-ba11a549c74a497180f79ec4e6f5913f |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:31:19Z |
| publishDate | 2016-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-ba11a549c74a497180f79ec4e6f5913f2024-04-15T13:55:56ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512016-01-0155.2.33433710.20471/acc.2016.55.02.24Drug-induced oral ulcerations: case reportVanja Vučičević Boras0Snježana Židovec-Lepej1Branka Marinović2Sven Seiwerth3Ivana Škrinjar4Dražen Pulanić5Danica Vidović Juras6Department of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, CroatiaDepartment of Virology, Dr Fran Mihaljević Clinical Hospital for Infectious Diseases, Zagreb, CroatiaClinical Department of Dermatology and Venereology, Zagreb University Hospital Center, Zagreb, CroatiaDepartment of Pathology, Zagreb University Hospital Center, Zagreb, CroatiaDepartment of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, CroatiaDivision of Hematology, Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia ; Osijek School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatDepartment of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, CroatiaA 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers. One of the possible explanations was that the lesions were due to the use of drugs, the more so as oral lesions evolved when the doses of allopurinol and chlorambucil were increased, and subsided when the doses of both drugs were decreased. However, we could not establish for sure whether the lesions were due to allopurinol or chlorambucil. According to literature data, allopurinol is one of the most frequent drugs known to induce skin adverse reactions, therefore we assumed that it was the culprit drug. Unfortunately, several weeks later the patient died from sepsis, pneumonia with respiratory insufficiency and multiorgan failure.https://hrcak.srce.hr/file/243158Oral ulcerDrug-related side effects and adverse reactionsCase reports |
| spellingShingle | Vanja Vučičević Boras Snježana Židovec-Lepej Branka Marinović Sven Seiwerth Ivana Škrinjar Dražen Pulanić Danica Vidović Juras Drug-induced oral ulcerations: case report Acta Clinica Croatica Oral ulcer Drug-related side effects and adverse reactions Case reports |
| title | Drug-induced oral ulcerations: case report |
| title_full | Drug-induced oral ulcerations: case report |
| title_fullStr | Drug-induced oral ulcerations: case report |
| title_full_unstemmed | Drug-induced oral ulcerations: case report |
| title_short | Drug-induced oral ulcerations: case report |
| title_sort | drug induced oral ulcerations case report |
| topic | Oral ulcer Drug-related side effects and adverse reactions Case reports |
| url | https://hrcak.srce.hr/file/243158 |
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