Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan
Background: Lymphomatoid papulosis (LyP) is a rare condition within the spectrum of CD30+ cutaneous lymphoproliferative disorders that is not well documented in Taiwan. This study aimed to analyze its clinical manifestations, diagnostic histopathology, clinical course, and treatment response among T...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-03-01
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| Series: | Dermatologica Sinica |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811711000115 |
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| author | Jheng-Wei Lin Wen-Jin Shiau Ching-I. Lu Chang-You Tsai Wen-Ron Wong Rosaline Chung-Yee Hui |
| author_facet | Jheng-Wei Lin Wen-Jin Shiau Ching-I. Lu Chang-You Tsai Wen-Ron Wong Rosaline Chung-Yee Hui |
| author_sort | Jheng-Wei Lin |
| collection | DOAJ |
| description | Background: Lymphomatoid papulosis (LyP) is a rare condition within the spectrum of CD30+ cutaneous lymphoproliferative disorders that is not well documented in Taiwan. This study aimed to analyze its clinical manifestations, diagnostic histopathology, clinical course, and treatment response among Taiwanese.
Methods: A retrospective chart review was performed on patients diagnosed with LyP at a Taiwanese medical center from 1992 to 2008.
Results: There were 34 patients with biopsy-proven LyP. The mean age at diagnosis was 36 years (range: 10–75 years), with male predominance (male:female ratio 3:2). Type-A LyP was identified in 32 patients and Type C in 2 patients. Seven cases showed CD4 predominance and six cases showed CD8 predominance. Of the 34 LyP patients, 2 had coexistent non-Hodgkin’s lymphoma, 1 (3%, 1/34) diagnosed before LyP onset and 1 (3%, 1/34) developed lymphoma 3 years after LyP. All of the patients were alive after a mean of 5.2 years (range: 3–12.7 years) of follow-up.
Conclusions: Most of our cases are Type A LyP. No clinical features or pathologic features can predict increased risk for developing malignancy. Although only 6% (2/34) of LyP patients were found to have lymphoma in 3-year follow-up, longer follow up is needed. Regardless of treatment modalities, two-thirds of the patients have a recurrent and relapsing course. Observation is a reasonable approach for patients without cosmetic or symptomatic concerns. |
| first_indexed | 2024-12-12T10:11:33Z |
| format | Article |
| id | doaj.art-ba11f6d56b5041a6b55d12c8c124c444 |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-12T10:11:33Z |
| publishDate | 2011-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-ba11f6d56b5041a6b55d12c8c124c4442022-12-22T00:27:48ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172011-03-0129181210.1016/j.dsi.2011.02.001Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in TaiwanJheng-Wei Lin0Wen-Jin Shiau1Ching-I. Lu2Chang-You Tsai3Wen-Ron Wong4Rosaline Chung-Yee Hui5Department of Dermatology, Chang Gung Memorial Hospital, Keelung, TaiwanYin Chiao Huang Dermatology Clinic, Taipei, TaiwaniSkin Clinic, Taipei, TaiwanTsai’s Hair and Skin Clinic, Taipei, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, TaiwanDepartment of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, TaiwanBackground: Lymphomatoid papulosis (LyP) is a rare condition within the spectrum of CD30+ cutaneous lymphoproliferative disorders that is not well documented in Taiwan. This study aimed to analyze its clinical manifestations, diagnostic histopathology, clinical course, and treatment response among Taiwanese. Methods: A retrospective chart review was performed on patients diagnosed with LyP at a Taiwanese medical center from 1992 to 2008. Results: There were 34 patients with biopsy-proven LyP. The mean age at diagnosis was 36 years (range: 10–75 years), with male predominance (male:female ratio 3:2). Type-A LyP was identified in 32 patients and Type C in 2 patients. Seven cases showed CD4 predominance and six cases showed CD8 predominance. Of the 34 LyP patients, 2 had coexistent non-Hodgkin’s lymphoma, 1 (3%, 1/34) diagnosed before LyP onset and 1 (3%, 1/34) developed lymphoma 3 years after LyP. All of the patients were alive after a mean of 5.2 years (range: 3–12.7 years) of follow-up. Conclusions: Most of our cases are Type A LyP. No clinical features or pathologic features can predict increased risk for developing malignancy. Although only 6% (2/34) of LyP patients were found to have lymphoma in 3-year follow-up, longer follow up is needed. Regardless of treatment modalities, two-thirds of the patients have a recurrent and relapsing course. Observation is a reasonable approach for patients without cosmetic or symptomatic concerns.http://www.sciencedirect.com/science/article/pii/S1027811711000115Lymphomatoid papulosisLymphoproliferative disorderNon-Hodgkin’s lymphoma |
| spellingShingle | Jheng-Wei Lin Wen-Jin Shiau Ching-I. Lu Chang-You Tsai Wen-Ron Wong Rosaline Chung-Yee Hui Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan Dermatologica Sinica Lymphomatoid papulosis Lymphoproliferative disorder Non-Hodgkin’s lymphoma |
| title | Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan |
| title_full | Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan |
| title_fullStr | Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan |
| title_full_unstemmed | Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan |
| title_short | Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan |
| title_sort | lymphomatoid papulosis a clinical and histopathologic review and follow up study of 34 cases in taiwan |
| topic | Lymphomatoid papulosis Lymphoproliferative disorder Non-Hodgkin’s lymphoma |
| url | http://www.sciencedirect.com/science/article/pii/S1027811711000115 |
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