Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
More than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03247-3 |
| _version_ | 1818343722908123136 |
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| author | Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo |
| author_facet | Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo |
| author_sort | Cui-Ping Yang |
| collection | DOAJ |
| description | More than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells. |
| first_indexed | 2024-12-13T16:35:06Z |
| format | Article |
| id | doaj.art-ba12e6b9e8a940f9954895f9f71b1408 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:35:06Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ba12e6b9e8a940f9954895f9f71b14082022-12-21T23:38:25ZengNature PortfolioNature Communications2041-17232018-02-019111610.1038/s41467-018-03247-3Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genesCui-Ping Yang0Xiaoyan Li1Yong Wu2Qiushuo Shen3Yong Zeng4Qiuxia Xiong5Mengping Wei6Chunhui Chen7Jiewei Liu8Yongxia Huo9Kaiqin Li10Gui Xue11Yong-Gang Yao12Chen Zhang13Ming Li14Yongbin Chen15Xiong-Jian Luo16Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical CollegeDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical CollegeState Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences, Peking UniversityState Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences, Peking UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesMore than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.https://doi.org/10.1038/s41467-018-03247-3 |
| spellingShingle | Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes Nature Communications |
| title | Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes |
| title_full | Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes |
| title_fullStr | Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes |
| title_full_unstemmed | Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes |
| title_short | Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes |
| title_sort | comprehensive integrative analyses identify glt8d1 and csnk2b as schizophrenia risk genes |
| url | https://doi.org/10.1038/s41467-018-03247-3 |
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