NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59

NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59

Abstract Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance. Previously, we have demonstrated that immunoediting driven by cytotoxic T lymphocytes (CTLs) enriches NANOG+ tumor cells with immune-refractory properties. Here, we found that CTL-mediated immune pressure...

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Bibliographic Details
Main Authors: Sung Wook Son, Eunho Cho, Hanbyoul Cho, Seon Rang Woo, Hyo-Jung Lee, Se Jin Oh, Suyeon Kim, Jae-Hoon Kim, Eun Joo Chung, Joon-Yong Chung, Min Gyu Kim, Kwon-Ho Song, Tae Woo Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12692-6

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