Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods

Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods

The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson’s disease. The active pharmaceutical ingredient (API) and one of the polymers polyvinyl alcohol (PVA) or basic butylated methacrylate copolym...

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Bibliographic Details
Main Authors: Rebecca Chamberlain, Hellen Windolf, Simon Geissler, Julian Quodbach, Jörg Breitkreutz
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
hot melt extrusion
low-dosed filament production
analytics of extruded filaments
fused filament 3D printing
oral dosage form
various dosing techniques
Online Access:https://www.mdpi.com/1999-4923/14/1/216

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