Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study
In the current study, we sought to track the clinical course of children under control-based asthma management and focused on respiratory pathogens monitoring. We prospectively explored influencing factors for asthma control. 121 children with uncontrolled asthma between 3-14 years of age were recru...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2018-02-01
|
| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1328 |
| _version_ | 1818934476530515968 |
|---|---|
| author | Qi Gao Huijie Huang Kang Zhu Xiaoying Liu Xiaoling Hou Hui Guan Yongge Liu Deli Xin Li Xiang Kunling Shen Xin Ni |
| author_facet | Qi Gao Huijie Huang Kang Zhu Xiaoying Liu Xiaoling Hou Hui Guan Yongge Liu Deli Xin Li Xiang Kunling Shen Xin Ni |
| author_sort | Qi Gao |
| collection | DOAJ |
| description | In the current study, we sought to track the clinical course of children under control-based asthma management and focused on respiratory pathogens monitoring. We prospectively explored influencing factors for asthma control. 121 children with uncontrolled asthma between 3-14 years of age were recruited. Common respiratory pathogens were detected with pharyngeal swabs and serum aeroallergen-specific IgE was measured. Numeric asthma control scores, airway resistance and fractional concentrations of exhaled nitric oxide (FENO) were evaluated. A proper control-based asthma management plan was established by the study physician. Regular reviews were performed, with the above measurements retested at set time intervals. The proportion of patients achieving asthma control at 1 month and 3 months were 59% and 76% ; respectively (p=0.013). These patients exhibited significant improvement in numeric scores and lung function parameters. The prevalence of common respiratory pathogens did not significantly differ between reviews. The number of sensitized aeroallergens significantly increased with age (r=0.235, p=0.010). Children with a high visual analogue scale (VAS) score for asthma at baseline were less likely to achieve asthma control after 1 month, while those sensitized to more aeroallergens were more likely to achieve asthma control after 1 month (p=0.016 and 0.012). In summary, children with asthma showed significant improvements in control rates and lung function during control-based asthma management, independent of respiratory pathogens testing reults. Patients with high VAS scores and fewer sensitizations to aeroallergens had difficulty achieving short-term asthma control. |
| first_indexed | 2024-12-20T05:04:53Z |
| format | Article |
| id | doaj.art-ba15aefa5d4e4a90a2a41f5d99da79b8 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-20T05:04:53Z |
| publishDate | 2018-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-ba15aefa5d4e4a90a2a41f5d99da79b82022-12-21T19:52:25ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492018-02-011711328Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective StudyQi Gao0Huijie Huang1Kang Zhu2Xiaoying Liu3Xiaoling Hou4Hui Guan5Yongge Liu6Deli Xin7Li Xiang8Kunling Shen9Xin Ni10Respiratory Department, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Allergy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China AND China National Clinical Research Center for Respiratory Diseases, Beijing, ChinaRespiratory Department, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China AND China National Clinical Research Center for Respiratory Diseases, Beijing, ChinaOtolaryngology Head and Neck Surgery Department, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaIn the current study, we sought to track the clinical course of children under control-based asthma management and focused on respiratory pathogens monitoring. We prospectively explored influencing factors for asthma control. 121 children with uncontrolled asthma between 3-14 years of age were recruited. Common respiratory pathogens were detected with pharyngeal swabs and serum aeroallergen-specific IgE was measured. Numeric asthma control scores, airway resistance and fractional concentrations of exhaled nitric oxide (FENO) were evaluated. A proper control-based asthma management plan was established by the study physician. Regular reviews were performed, with the above measurements retested at set time intervals. The proportion of patients achieving asthma control at 1 month and 3 months were 59% and 76% ; respectively (p=0.013). These patients exhibited significant improvement in numeric scores and lung function parameters. The prevalence of common respiratory pathogens did not significantly differ between reviews. The number of sensitized aeroallergens significantly increased with age (r=0.235, p=0.010). Children with a high visual analogue scale (VAS) score for asthma at baseline were less likely to achieve asthma control after 1 month, while those sensitized to more aeroallergens were more likely to achieve asthma control after 1 month (p=0.016 and 0.012). In summary, children with asthma showed significant improvements in control rates and lung function during control-based asthma management, independent of respiratory pathogens testing reults. Patients with high VAS scores and fewer sensitizations to aeroallergens had difficulty achieving short-term asthma control.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1328AsthmaPediatrics respiratory function testsRespiratory pathogenSensitizationVisual analogue scale |
| spellingShingle | Qi Gao Huijie Huang Kang Zhu Xiaoying Liu Xiaoling Hou Hui Guan Yongge Liu Deli Xin Li Xiang Kunling Shen Xin Ni Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study Iranian Journal of Allergy, Asthma and Immunology Asthma Pediatrics respiratory function tests Respiratory pathogen Sensitization Visual analogue scale |
| title | Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study |
| title_full | Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study |
| title_fullStr | Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study |
| title_full_unstemmed | Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study |
| title_short | Clinical Course and Factors Associated with Asthma Control in Children under Control-based Asthma Management: A Prospective Study |
| title_sort | clinical course and factors associated with asthma control in children under control based asthma management a prospective study |
| topic | Asthma Pediatrics respiratory function tests Respiratory pathogen Sensitization Visual analogue scale |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1328 |
| work_keys_str_mv | AT qigao clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT huijiehuang clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT kangzhu clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT xiaoyingliu clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT xiaolinghou clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT huiguan clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT yonggeliu clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT delixin clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT lixiang clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT kunlingshen clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy AT xinni clinicalcourseandfactorsassociatedwithasthmacontrolinchildrenundercontrolbasedasthmamanagementaprospectivestudy |