Therapeutic neovascularization promoted by injectable hydrogels
The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2018-12-01
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| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X17301202 |
| _version_ | 1797203385758253056 |
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| author | Amrita Pal Brent L. Vernon Mehdi Nikkhah |
| author_facet | Amrita Pal Brent L. Vernon Mehdi Nikkhah |
| author_sort | Amrita Pal |
| collection | DOAJ |
| description | The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors. Keywords: Injectable hydrogels, Neovascularization, Tissue regeneration, Angiogenic factors, Cell-therapy |
| first_indexed | 2024-04-24T08:18:30Z |
| format | Article |
| id | doaj.art-ba15f80714554b72a488baa40e49f9b0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:18:30Z |
| publishDate | 2018-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-ba15f80714554b72a488baa40e49f9b02024-04-17T02:37:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2018-12-0134389400Therapeutic neovascularization promoted by injectable hydrogelsAmrita Pal0Brent L. Vernon1Mehdi Nikkhah2School of Biological and Health Systems Engineering, Arizona State University, Arizona 85281, USACorresponding author.; School of Biological and Health Systems Engineering, Arizona State University, Arizona 85281, USACorresponding author.; School of Biological and Health Systems Engineering, Arizona State University, Arizona 85281, USAThe aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors. Keywords: Injectable hydrogels, Neovascularization, Tissue regeneration, Angiogenic factors, Cell-therapyhttp://www.sciencedirect.com/science/article/pii/S2452199X17301202 |
| spellingShingle | Amrita Pal Brent L. Vernon Mehdi Nikkhah Therapeutic neovascularization promoted by injectable hydrogels Bioactive Materials |
| title | Therapeutic neovascularization promoted by injectable hydrogels |
| title_full | Therapeutic neovascularization promoted by injectable hydrogels |
| title_fullStr | Therapeutic neovascularization promoted by injectable hydrogels |
| title_full_unstemmed | Therapeutic neovascularization promoted by injectable hydrogels |
| title_short | Therapeutic neovascularization promoted by injectable hydrogels |
| title_sort | therapeutic neovascularization promoted by injectable hydrogels |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X17301202 |
| work_keys_str_mv | AT amritapal therapeuticneovascularizationpromotedbyinjectablehydrogels AT brentlvernon therapeuticneovascularizationpromotedbyinjectablehydrogels AT mehdinikkhah therapeuticneovascularizationpromotedbyinjectablehydrogels |