Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Background: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we wil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/5/924 |
| _version_ | 1797499591322501120 |
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| author | Mati Chuamanochan Sutthinee Phuprasertsak Puncharas Weesasubpong Chidchanok Ruengorn Chabaphai Phosuya Ratanaporn Awiphan Brian Hutton Kednapa Thavorn Jonathan A. Bernstein Surapon Nochaiwong |
| author_facet | Mati Chuamanochan Sutthinee Phuprasertsak Puncharas Weesasubpong Chidchanok Ruengorn Chabaphai Phosuya Ratanaporn Awiphan Brian Hutton Kednapa Thavorn Jonathan A. Bernstein Surapon Nochaiwong |
| author_sort | Mati Chuamanochan |
| collection | DOAJ |
| description | Background: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we will perform a systematic review and network meta-analysis to identify the best evidence-based treatments for the management of acute attacks and prophylaxis of HAE. Methods: This study will include both parallel and crossover randomized controlled trials that have investigated prevention or treatment strategies for HAE attacks. We will search electronic databases, including Medline, Embase, PubMed, Cochrane Library, Scopus, and CINAHL, from inception with no language restrictions. Potential trials will be supplemented through a gray literature search. The process of study screening, selection, data extraction, risk-of-bias assessment, certainty assessment and classification of treatments will be performed independently by a pair of reviewers. Any discrepancy will be addressed through team discussion. A two-step approach of pairwise and network meta-analysis will be performed. The summarized effect estimates of direct and indirect treatment comparisons will be pooled using DerSimonion–Laird random-effects models. The incoherence assumption, in terms of the consistency of direct and indirect effects, will be assessed. An evidence-based synthesis will be performed, based on the magnitudes of effect size, evidence certainty, and ranking of treatment effects, with respect to treatment benefits and harms. Discussion: This systematic review and network meta-analysis will summarize evidence-based conclusions with respect to the ratio of benefits and harms arising from interventions for the treatment of acute attacks and prophylaxis of HAE. Evidence from this network estimate could promote the rational use of interventions among people living with HAE in clinical practice settings. PROSPERO registration number: CRD42021251367. |
| first_indexed | 2024-03-10T03:49:36Z |
| format | Article |
| id | doaj.art-ba18007fb5984eb4bcbcb1d2f4be7ac2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T03:49:36Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ba18007fb5984eb4bcbcb1d2f4be7ac22023-11-23T11:11:40ZengMDPI AGGenes2073-44252022-05-0113592410.3390/genes13050924Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled TrialsMati Chuamanochan0Sutthinee Phuprasertsak1Puncharas Weesasubpong2Chidchanok Ruengorn3Chabaphai Phosuya4Ratanaporn Awiphan5Brian Hutton6Kednapa Thavorn7Jonathan A. Bernstein8Surapon Nochaiwong9Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandMaharaj Nakorn Chiang Mai Hospital, Chiang Mai 50200, ThailandPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandOttawa Hospital Research Institute, Ottawa Hospital, Ottawa, ON K1H 8L6, CanadaPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandAllergy Section, Division of Immunology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USAPharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, ThailandBackground: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we will perform a systematic review and network meta-analysis to identify the best evidence-based treatments for the management of acute attacks and prophylaxis of HAE. Methods: This study will include both parallel and crossover randomized controlled trials that have investigated prevention or treatment strategies for HAE attacks. We will search electronic databases, including Medline, Embase, PubMed, Cochrane Library, Scopus, and CINAHL, from inception with no language restrictions. Potential trials will be supplemented through a gray literature search. The process of study screening, selection, data extraction, risk-of-bias assessment, certainty assessment and classification of treatments will be performed independently by a pair of reviewers. Any discrepancy will be addressed through team discussion. A two-step approach of pairwise and network meta-analysis will be performed. The summarized effect estimates of direct and indirect treatment comparisons will be pooled using DerSimonion–Laird random-effects models. The incoherence assumption, in terms of the consistency of direct and indirect effects, will be assessed. An evidence-based synthesis will be performed, based on the magnitudes of effect size, evidence certainty, and ranking of treatment effects, with respect to treatment benefits and harms. Discussion: This systematic review and network meta-analysis will summarize evidence-based conclusions with respect to the ratio of benefits and harms arising from interventions for the treatment of acute attacks and prophylaxis of HAE. Evidence from this network estimate could promote the rational use of interventions among people living with HAE in clinical practice settings. PROSPERO registration number: CRD42021251367.https://www.mdpi.com/2073-4425/13/5/924complement 1 inhibitor deficiencyeffectivenessgenetic diseaseharmshereditary angioedemasystematic review |
| spellingShingle | Mati Chuamanochan Sutthinee Phuprasertsak Puncharas Weesasubpong Chidchanok Ruengorn Chabaphai Phosuya Ratanaporn Awiphan Brian Hutton Kednapa Thavorn Jonathan A. Bernstein Surapon Nochaiwong Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Genes complement 1 inhibitor deficiency effectiveness genetic disease harms hereditary angioedema systematic review |
| title | Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials |
| title_full | Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials |
| title_short | Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials |
| title_sort | benefits and harms of treatment and preventive interventions for hereditary angioedema protocol for a systematic review and network meta analysis of randomized controlled trials |
| topic | complement 1 inhibitor deficiency effectiveness genetic disease harms hereditary angioedema systematic review |
| url | https://www.mdpi.com/2073-4425/13/5/924 |
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