Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis
Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary...
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine
2020-10-01
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| Series: | Yeungnam University Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.e-yujm.org/upload/pdf/yujm-2020-00458.pdf |
| _version_ | 1818040396569116672 |
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| author | Suji Kim Jae Hyang Lim Chang-Hoon Woo |
| author_facet | Suji Kim Jae Hyang Lim Chang-Hoon Woo |
| author_sort | Suji Kim |
| collection | DOAJ |
| description | Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the role of kinase signaling cascades in the regulation of either TGF-β-dependent or other signaling pathways, including Rho-associated coiled-coil kinase, c-jun N-terminal kinase, extracellular signal-regulated kinase 5, and p90 ribosomal S6 kinase pathways, and potential therapeutic targets in IPF. |
| first_indexed | 2024-12-10T08:13:52Z |
| format | Article |
| id | doaj.art-ba19b8acbd704e6b86da1cf985dfbedb |
| institution | Directory Open Access Journal |
| issn | 2384-0293 |
| language | English |
| last_indexed | 2024-12-10T08:13:52Z |
| publishDate | 2020-10-01 |
| publisher | Yeungnam University College of Medicine |
| record_format | Article |
| series | Yeungnam University Journal of Medicine |
| spelling | doaj.art-ba19b8acbd704e6b86da1cf985dfbedb2022-12-22T01:56:30ZengYeungnam University College of MedicineYeungnam University Journal of Medicine2384-02932020-10-0137426927610.12701/yujm.2020.004582503Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosisSuji Kim0Jae Hyang Lim1Chang-Hoon Woo2 Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine, Daegu, Korea Department of Microbiology, Ewha Womans University College of Medicine, Seoul, Korea Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine, Daegu, KoreaFibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-β) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the role of kinase signaling cascades in the regulation of either TGF-β-dependent or other signaling pathways, including Rho-associated coiled-coil kinase, c-jun N-terminal kinase, extracellular signal-regulated kinase 5, and p90 ribosomal S6 kinase pathways, and potential therapeutic targets in IPF.http://www.e-yujm.org/upload/pdf/yujm-2020-00458.pdffibrosisidiopathic pulmonary fibrosiskinasetransforming growth factor beta |
| spellingShingle | Suji Kim Jae Hyang Lim Chang-Hoon Woo Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis Yeungnam University Journal of Medicine fibrosis idiopathic pulmonary fibrosis kinase transforming growth factor beta |
| title | Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| title_full | Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| title_fullStr | Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| title_full_unstemmed | Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| title_short | Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| title_sort | therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis |
| topic | fibrosis idiopathic pulmonary fibrosis kinase transforming growth factor beta |
| url | http://www.e-yujm.org/upload/pdf/yujm-2020-00458.pdf |
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