Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly
Abstract Background To evaluate anterior synechiae after penetrating keratoplasty (PK) in patients with Peters’ anomaly using anterior segment optical coherence tomography (OCT). Methods A retrospective cross-sectional study was performed. The medical records of patients diagnosed with Peters’ anoma...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02473-0 |
| _version_ | 1828333762758311936 |
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| author | Yujing Yang Jun Xiang Jianjiang Xu |
| author_facet | Yujing Yang Jun Xiang Jianjiang Xu |
| author_sort | Yujing Yang |
| collection | DOAJ |
| description | Abstract Background To evaluate anterior synechiae after penetrating keratoplasty (PK) in patients with Peters’ anomaly using anterior segment optical coherence tomography (OCT). Methods A retrospective cross-sectional study was performed. The medical records of patients diagnosed with Peters’ anomaly who underwent PK between 2013 and 2018 were reviewed. In addition to basic ophthalmic examinations, images of anterior segment structures were obtained via spectral-domain OCT at baseline and during the postoperative follow-up period. The profiles of postoperative anterior synechiae and multiple potential risk factors were analyzed. Results Seventy-one eyes of 58 patients, aged 5 to 23 months, were included. Various extent of postoperative anterior synechiae was observed in 59 eyes (83.1%). OCT findings revealed graft-host junction synechiae, peripheral anterior synechiae, and a combination of both. Disease severity and malposition of the internal graft-host junction were significantly associated with the formation of postoperative synechiae. Multivariate regression analysis found that preexisting iridocorneal adhesion [odds ratio (OR) = 16.639, 95% confidence interval (CI) 1.494–185.294, p = 0.022] was positively correlated with postoperative anterior synechiae, whereas anterior chamber depth (OR = 0.009, 95% CI 0.000–0.360, p = 0.012) and graft size (OR = 0.016, 95% CI 0.000–0.529, p = 0.020) were negatively correlated with postoperative synechiae. In addition, quadrants of preexisting iridocorneal adhesion and width of the host corneal bed were identified as risk factors for increased postoperative anterior synechiae. Conclusions Anterior synechiae following PK is a relatively common occurrence in Peters’ anomaly patients and is found to be associated with preexisting iridocorneal adhesion, a shallow anterior chamber, small graft size, graft-host junction malposition, and graft closer to the corneal limbus. These data indicate the need for careful consideration when performing PK on these patients. |
| first_indexed | 2024-04-13T21:25:17Z |
| format | Article |
| id | doaj.art-ba1a3839d24f4afb86b4e47d23ee5c99 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T21:25:17Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-ba1a3839d24f4afb86b4e47d23ee5c992022-12-22T02:29:21ZengBMCBMC Ophthalmology1471-24152022-06-0122111010.1186/s12886-022-02473-0Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomalyYujing Yang0Jun Xiang1Jianjiang Xu2Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan UniversityDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan UniversityAbstract Background To evaluate anterior synechiae after penetrating keratoplasty (PK) in patients with Peters’ anomaly using anterior segment optical coherence tomography (OCT). Methods A retrospective cross-sectional study was performed. The medical records of patients diagnosed with Peters’ anomaly who underwent PK between 2013 and 2018 were reviewed. In addition to basic ophthalmic examinations, images of anterior segment structures were obtained via spectral-domain OCT at baseline and during the postoperative follow-up period. The profiles of postoperative anterior synechiae and multiple potential risk factors were analyzed. Results Seventy-one eyes of 58 patients, aged 5 to 23 months, were included. Various extent of postoperative anterior synechiae was observed in 59 eyes (83.1%). OCT findings revealed graft-host junction synechiae, peripheral anterior synechiae, and a combination of both. Disease severity and malposition of the internal graft-host junction were significantly associated with the formation of postoperative synechiae. Multivariate regression analysis found that preexisting iridocorneal adhesion [odds ratio (OR) = 16.639, 95% confidence interval (CI) 1.494–185.294, p = 0.022] was positively correlated with postoperative anterior synechiae, whereas anterior chamber depth (OR = 0.009, 95% CI 0.000–0.360, p = 0.012) and graft size (OR = 0.016, 95% CI 0.000–0.529, p = 0.020) were negatively correlated with postoperative synechiae. In addition, quadrants of preexisting iridocorneal adhesion and width of the host corneal bed were identified as risk factors for increased postoperative anterior synechiae. Conclusions Anterior synechiae following PK is a relatively common occurrence in Peters’ anomaly patients and is found to be associated with preexisting iridocorneal adhesion, a shallow anterior chamber, small graft size, graft-host junction malposition, and graft closer to the corneal limbus. These data indicate the need for careful consideration when performing PK on these patients.https://doi.org/10.1186/s12886-022-02473-0Peters’ anomalyCongenital corneal opacityPenetrating keratoplastyOptical coherence tomography |
| spellingShingle | Yujing Yang Jun Xiang Jianjiang Xu Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly BMC Ophthalmology Peters’ anomaly Congenital corneal opacity Penetrating keratoplasty Optical coherence tomography |
| title | Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly |
| title_full | Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly |
| title_fullStr | Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly |
| title_full_unstemmed | Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly |
| title_short | Anterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly |
| title_sort | anterior synechiae after penetrating keratoplasty in infants and children with peters anomaly |
| topic | Peters’ anomaly Congenital corneal opacity Penetrating keratoplasty Optical coherence tomography |
| url | https://doi.org/10.1186/s12886-022-02473-0 |
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