Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis
Plasmablastic lymphoma (PBL) is a distinctly rare neoplasm believed to arise from post-germinal center, terminally differentiated, activated B cells before transformation to plasma cells; and predominantly affecting human immunodeficiency virus (HIV) infected or immunodeficient males. Here, we repor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=1;spage=107;epage=110;aulast=Sharma |
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| author | Praveen Sharma Sreejesh Sreedharanunni Abin Koshy Gaurav Prakash Man Updesh Singh Sachdeva Pankaj Malhotra |
| author_facet | Praveen Sharma Sreejesh Sreedharanunni Abin Koshy Gaurav Prakash Man Updesh Singh Sachdeva Pankaj Malhotra |
| author_sort | Praveen Sharma |
| collection | DOAJ |
| description | Plasmablastic lymphoma (PBL) is a distinctly rare neoplasm believed to arise from post-germinal center, terminally differentiated, activated B cells before transformation to plasma cells; and predominantly affecting human immunodeficiency virus (HIV) infected or immunodeficient males. Here, we report a rare case of primary PBL of bone marrow in an immunocompetent male, the diagnosis of which is complicated by the overlapping morphology and immunophenotype with several large cell lymphomas and plasma cell neoplasms; and showing dramatic response to anti-CD30 monoclonal antibody based therapy. We discuss the immunohistochemistry based approach and the possible diagnostic pitfalls in such cases. The inclusion of markers of plasmablastic differentiation in the diagnostic panel of large cell lymphomas is essential to avoid misclassification of these rare lymphomas. |
| first_indexed | 2024-12-12T19:04:13Z |
| format | Article |
| id | doaj.art-ba1b0805195e47b3ba353c546c484ca5 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-12T19:04:13Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-ba1b0805195e47b3ba353c546c484ca52022-12-22T00:14:59ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292019-01-0162110711010.4103/IJPM.IJPM_180_18Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosisPraveen SharmaSreejesh SreedharanunniAbin KoshyGaurav PrakashMan Updesh Singh SachdevaPankaj MalhotraPlasmablastic lymphoma (PBL) is a distinctly rare neoplasm believed to arise from post-germinal center, terminally differentiated, activated B cells before transformation to plasma cells; and predominantly affecting human immunodeficiency virus (HIV) infected or immunodeficient males. Here, we report a rare case of primary PBL of bone marrow in an immunocompetent male, the diagnosis of which is complicated by the overlapping morphology and immunophenotype with several large cell lymphomas and plasma cell neoplasms; and showing dramatic response to anti-CD30 monoclonal antibody based therapy. We discuss the immunohistochemistry based approach and the possible diagnostic pitfalls in such cases. The inclusion of markers of plasmablastic differentiation in the diagnostic panel of large cell lymphomas is essential to avoid misclassification of these rare lymphomas.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=1;spage=107;epage=110;aulast=SharmaAnti-CD30 monoclonal antibodyimmunohistochemistryplasmablastic lymphoma |
| spellingShingle | Praveen Sharma Sreejesh Sreedharanunni Abin Koshy Gaurav Prakash Man Updesh Singh Sachdeva Pankaj Malhotra Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis Indian Journal of Pathology and Microbiology Anti-CD30 monoclonal antibody immunohistochemistry plasmablastic lymphoma |
| title | Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis |
| title_full | Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis |
| title_fullStr | Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis |
| title_full_unstemmed | Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis |
| title_short | Plasmablastic lymphoma of bone marrow: Report of a rare case and immunohistochemistry based approach to the diagnosis |
| title_sort | plasmablastic lymphoma of bone marrow report of a rare case and immunohistochemistry based approach to the diagnosis |
| topic | Anti-CD30 monoclonal antibody immunohistochemistry plasmablastic lymphoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=1;spage=107;epage=110;aulast=Sharma |
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