The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology
Pentraxins are a superfamily of evolutionarily conserved proteins that are characterized by their multimeric architecture and their calcium-dependent binding. They can be broadly grouped into two subfamilies: short pentraxins and long pentraxins. Pentraxins regulate many processes in the brain as we...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00575/full |
| _version_ | 1818126707882721280 |
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| author | Georgina Chapman Ushananthini Shanmugalingam Patrice D. Smith |
| author_facet | Georgina Chapman Ushananthini Shanmugalingam Patrice D. Smith |
| author_sort | Georgina Chapman |
| collection | DOAJ |
| description | Pentraxins are a superfamily of evolutionarily conserved proteins that are characterized by their multimeric architecture and their calcium-dependent binding. They can be broadly grouped into two subfamilies: short pentraxins and long pentraxins. Pentraxins regulate many processes in the brain as well as the periphery. Neuronal pentraxin 2 (NP2/NPTX2), also known as neuronal activity-regulated pentraxin (Narp), is an immediate-early gene that has been shown to play a critical role in guiding synaptic plasticity. NP2 has been previously linked to excitatory neurotransmission, based on its ability to aggregate excitatory receptors in the central nervous system. The mechanisms mediating the effects of NP2 on excitatory neurotransmission remain unclear and warrants further investigation. This review article focuses on the biological features of NP2 and discusses the literature supporting a role for NP2 and other pentraxins in glutamatergic signaling. An analysis of evidence around the role of pentraxins in neuropathology is also reviewed. |
| first_indexed | 2024-12-11T07:05:45Z |
| format | Article |
| id | doaj.art-ba1bdb031eaa4cd0add17a4f7a9749e7 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T07:05:45Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-ba1bdb031eaa4cd0add17a4f7a9749e72022-12-22T01:16:30ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-01-011310.3389/fncel.2019.00575492162The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and NeuropathologyGeorgina ChapmanUshananthini ShanmugalingamPatrice D. SmithPentraxins are a superfamily of evolutionarily conserved proteins that are characterized by their multimeric architecture and their calcium-dependent binding. They can be broadly grouped into two subfamilies: short pentraxins and long pentraxins. Pentraxins regulate many processes in the brain as well as the periphery. Neuronal pentraxin 2 (NP2/NPTX2), also known as neuronal activity-regulated pentraxin (Narp), is an immediate-early gene that has been shown to play a critical role in guiding synaptic plasticity. NP2 has been previously linked to excitatory neurotransmission, based on its ability to aggregate excitatory receptors in the central nervous system. The mechanisms mediating the effects of NP2 on excitatory neurotransmission remain unclear and warrants further investigation. This review article focuses on the biological features of NP2 and discusses the literature supporting a role for NP2 and other pentraxins in glutamatergic signaling. An analysis of evidence around the role of pentraxins in neuropathology is also reviewed.https://www.frontiersin.org/article/10.3389/fncel.2019.00575/fullAMPA receptorNarpneuronal pentraxinsglutamatergic neurotransmissionexcitotoxicityneuropathology |
| spellingShingle | Georgina Chapman Ushananthini Shanmugalingam Patrice D. Smith The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology Frontiers in Cellular Neuroscience AMPA receptor Narp neuronal pentraxins glutamatergic neurotransmission excitotoxicity neuropathology |
| title | The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology |
| title_full | The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology |
| title_fullStr | The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology |
| title_full_unstemmed | The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology |
| title_short | The Role of Neuronal Pentraxin 2 (NP2) in Regulating Glutamatergic Signaling and Neuropathology |
| title_sort | role of neuronal pentraxin 2 np2 in regulating glutamatergic signaling and neuropathology |
| topic | AMPA receptor Narp neuronal pentraxins glutamatergic neurotransmission excitotoxicity neuropathology |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00575/full |
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