Interleukin-35 on B cell and T cell induction and regulation
Abstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12950-017-0164-5 |
| _version_ | 1819135063317544960 |
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| author | Ai Huang Lin Cheng Miao He Jun Nie Jianjun Wang Ke Jiang |
| author_facet | Ai Huang Lin Cheng Miao He Jun Nie Jianjun Wang Ke Jiang |
| author_sort | Ai Huang |
| collection | DOAJ |
| description | Abstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body. |
| first_indexed | 2024-12-22T10:13:07Z |
| format | Article |
| id | doaj.art-ba1cb2aaa4fe4124ae1ca019eb35782d |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-12-22T10:13:07Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-ba1cb2aaa4fe4124ae1ca019eb35782d2022-12-21T18:29:49ZengBMCJournal of Inflammation1476-92552017-08-011411710.1186/s12950-017-0164-5Interleukin-35 on B cell and T cell induction and regulationAi Huang0Lin Cheng1Miao He2Jun Nie3Jianjun Wang4Ke Jiang5Department of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Union hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body.http://link.springer.com/article/10.1186/s12950-017-0164-5Interleukin −35B cellsT cells |
| spellingShingle | Ai Huang Lin Cheng Miao He Jun Nie Jianjun Wang Ke Jiang Interleukin-35 on B cell and T cell induction and regulation Journal of Inflammation Interleukin −35 B cells T cells |
| title | Interleukin-35 on B cell and T cell induction and regulation |
| title_full | Interleukin-35 on B cell and T cell induction and regulation |
| title_fullStr | Interleukin-35 on B cell and T cell induction and regulation |
| title_full_unstemmed | Interleukin-35 on B cell and T cell induction and regulation |
| title_short | Interleukin-35 on B cell and T cell induction and regulation |
| title_sort | interleukin 35 on b cell and t cell induction and regulation |
| topic | Interleukin −35 B cells T cells |
| url | http://link.springer.com/article/10.1186/s12950-017-0164-5 |
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