Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health
Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong prognosticator for cardiovascular events and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.778762/full |
| _version_ | 1818059252617445376 |
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| author | Anum S. Minhas Anum S. Minhas Erin Goerlich Mary C. Corretti Armin Arbab-Zadeh Sebastian Kelle Thorsten Leucker Amir Lerman Allison G. Hays |
| author_facet | Anum S. Minhas Anum S. Minhas Erin Goerlich Mary C. Corretti Armin Arbab-Zadeh Sebastian Kelle Thorsten Leucker Amir Lerman Allison G. Hays |
| author_sort | Anum S. Minhas |
| collection | DOAJ |
| description | Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong prognosticator for cardiovascular events and mortality, and assessment of endothelial function can aid in selecting therapies and testing their response. While the gold standard method of measuring coronary endothelial function remains invasive angiography, several non-invasive imaging techniques have emerged for investigating both coronary and peripheral endothelial function. In this review, we will explore and summarize the current invasive and non-invasive modalities available for endothelial function assessment for clinical and research use, and discuss the strengths, limitations and future applications of each technique. |
| first_indexed | 2024-12-10T13:13:34Z |
| format | Article |
| id | doaj.art-ba1cb475901d4ec1aa74b5f9d22d9941 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-10T13:13:34Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ba1cb475901d4ec1aa74b5f9d22d99412022-12-22T01:47:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.778762778762Imaging Assessment of Endothelial Function: An Index of Cardiovascular HealthAnum S. Minhas0Anum S. Minhas1Erin Goerlich2Mary C. Corretti3Armin Arbab-Zadeh4Sebastian Kelle5Thorsten Leucker6Amir Lerman7Allison G. Hays8Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United StatesDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, GermanyDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDivision of Ischemic Heart Disease and Critical Care, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United StatesDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United StatesEndothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases and can be observed in larger conduit arteries as well as smaller resistance vessels (microvascular dysfunction). The presence of endothelial dysfunction is a strong prognosticator for cardiovascular events and mortality, and assessment of endothelial function can aid in selecting therapies and testing their response. While the gold standard method of measuring coronary endothelial function remains invasive angiography, several non-invasive imaging techniques have emerged for investigating both coronary and peripheral endothelial function. In this review, we will explore and summarize the current invasive and non-invasive modalities available for endothelial function assessment for clinical and research use, and discuss the strengths, limitations and future applications of each technique.https://www.frontiersin.org/articles/10.3389/fcvm.2022.778762/fullcoronary MRIendothelial functionCADCMRvascular disease |
| spellingShingle | Anum S. Minhas Anum S. Minhas Erin Goerlich Mary C. Corretti Armin Arbab-Zadeh Sebastian Kelle Thorsten Leucker Amir Lerman Allison G. Hays Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health Frontiers in Cardiovascular Medicine coronary MRI endothelial function CAD CMR vascular disease |
| title | Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health |
| title_full | Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health |
| title_fullStr | Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health |
| title_full_unstemmed | Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health |
| title_short | Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health |
| title_sort | imaging assessment of endothelial function an index of cardiovascular health |
| topic | coronary MRI endothelial function CAD CMR vascular disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.778762/full |
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