IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling

IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling

Plasma IL-6 is elevated after myocardial infarction (MI) and is associated with increased morbidity and mortality. Which cardiac cell type preferentially contributes to IL-6 expression and how its production is regulated are largely unknown. Here, we studied the cellular source and purinergic regula...

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Bibliographic Details
Main Authors: Christina Alter, Anne-Sophie Henseler, Christoph Owenier, Julia Hesse, Zhaoping Ding, Tobias Lautwein, Jasmin Bahr, Sikander Hayat, Rafael Kramann, Eva Kostenis, Jürgen Scheller, Jürgen Schrader
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
Cardiology
Inflammation
Online Access:https://doi.org/10.1172/JCI163799

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