Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections
Bioprospecting of the marine environment for drug development has gained much attention in recent years owing to its massive chemical and biological diversity. Drugs for the treatment of skin and soft tissue infections have become part of the search, mainly with respect to enlarging the number of av...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/7/387 |
| _version_ | 1797588514524626944 |
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| author | Antje Labes |
| author_facet | Antje Labes |
| author_sort | Antje Labes |
| collection | DOAJ |
| description | Bioprospecting of the marine environment for drug development has gained much attention in recent years owing to its massive chemical and biological diversity. Drugs for the treatment of skin and soft tissue infections have become part of the search, mainly with respect to enlarging the number of available antibiotics, with a special focus on multidrug-resistant Gram-positive bacteria, being the major causative agents in this field. Marine resources offer novel natural products with distinct biological activities of pharmaceutical importance, having the chance to provide new chemical scaffolds and new modes of action. New studies advance the field by proposing new strategies derived from an ecosystemic understanding for preventive activities against biofilms and new compounds suitable as disinfectants, which sustain the natural flora of the skin. Still, the development of new compounds is often stuck at the discovery level, as marine biotechnology also needs to overcome technological bottlenecks in drug development. This review summarizes its potential and shows these bottlenecks and new approaches. |
| first_indexed | 2024-03-11T00:54:08Z |
| format | Article |
| id | doaj.art-ba22b22b8dfe44a887a00e9089157caf |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T00:54:08Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ba22b22b8dfe44a887a00e9089157caf2023-11-18T20:14:05ZengMDPI AGMarine Drugs1660-33972023-06-0121738710.3390/md21070387Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue InfectionsAntje Labes0Department of Energy and Biotechnology, Flensburg University of Applied Sciences ZAiT, Kanzleistraße 91-93, D-24943 Flensburg, GermanyBioprospecting of the marine environment for drug development has gained much attention in recent years owing to its massive chemical and biological diversity. Drugs for the treatment of skin and soft tissue infections have become part of the search, mainly with respect to enlarging the number of available antibiotics, with a special focus on multidrug-resistant Gram-positive bacteria, being the major causative agents in this field. Marine resources offer novel natural products with distinct biological activities of pharmaceutical importance, having the chance to provide new chemical scaffolds and new modes of action. New studies advance the field by proposing new strategies derived from an ecosystemic understanding for preventive activities against biofilms and new compounds suitable as disinfectants, which sustain the natural flora of the skin. Still, the development of new compounds is often stuck at the discovery level, as marine biotechnology also needs to overcome technological bottlenecks in drug development. This review summarizes its potential and shows these bottlenecks and new approaches.https://www.mdpi.com/1660-3397/21/7/387secondary productssustainable use of the seamarine biotechnologybottlenecksantibiotic resistance |
| spellingShingle | Antje Labes Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections Marine Drugs secondary products sustainable use of the sea marine biotechnology bottlenecks antibiotic resistance |
| title | Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections |
| title_full | Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections |
| title_fullStr | Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections |
| title_full_unstemmed | Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections |
| title_short | Marine Resources Offer New Compounds and Strategies for the Treatment of Skin and Soft Tissue Infections |
| title_sort | marine resources offer new compounds and strategies for the treatment of skin and soft tissue infections |
| topic | secondary products sustainable use of the sea marine biotechnology bottlenecks antibiotic resistance |
| url | https://www.mdpi.com/1660-3397/21/7/387 |
| work_keys_str_mv | AT antjelabes marineresourcesoffernewcompoundsandstrategiesforthetreatmentofskinandsofttissueinfections |