Visualization and Parametrization of the Motion Behaviour of Subviral Particles
The development of a drug against pathogens of hemorrhagic fever, like the Marburg virus, is a great challenge. Therefore, accurate knowledge of the properties of subviral particles in the host cell must be obtained. The base for subviral particle analysis is a special fluorescence microscopy techni...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2018-0086 |
| _version_ | 1797740470538862592 |
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| author | Kaak Michelle Rausch Andreas Müller Dennis Schanze Thomas |
| author_facet | Kaak Michelle Rausch Andreas Müller Dennis Schanze Thomas |
| author_sort | Kaak Michelle |
| collection | DOAJ |
| description | The development of a drug against pathogens of hemorrhagic fever, like the Marburg virus, is a great challenge. Therefore, accurate knowledge of the properties of subviral particles in the host cell must be obtained. The base for subviral particle analysis is a special fluorescence microscopy technique. In order to automate and visualize the subviral particles’ motion patterns, previously a tracking algorithm was developed. In this article a new algorithm to parameterize and visualize the achieved particle tracks is introduced. A good potential for a fast data recognition is shown, with constantly respecting a high usability for pharmaceutical researchers. This algorithm was tested on both simulated and real data and provides reproducible results. |
| first_indexed | 2024-03-12T14:12:55Z |
| format | Article |
| id | doaj.art-ba22e08e4a9741aaa28af13d62b59882 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-12T14:12:55Z |
| publishDate | 2018-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-ba22e08e4a9741aaa28af13d62b598822023-08-21T06:42:01ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042018-09-014135936210.1515/cdbme-2018-0086cdbme-2018-0086Visualization and Parametrization of the Motion Behaviour of Subviral ParticlesKaak Michelle0Rausch Andreas1Müller Dennis2Schanze Thomas3IBMT, FB LSE. Technische Hochschule Mittelhessen (THM), Wiesenstraße 14,Gießen, GermanyIBMT, FB LSE, Technische Hochschule Mittelhessen (THM),Gießen, GermanyIBMT, FB LSE, Technische Hochschule Mittelhessen (THM),Gießen, GermanyIBMT, FB LSE, Technische Hochschule Mittelhessen (THM),Gießen, GermanyThe development of a drug against pathogens of hemorrhagic fever, like the Marburg virus, is a great challenge. Therefore, accurate knowledge of the properties of subviral particles in the host cell must be obtained. The base for subviral particle analysis is a special fluorescence microscopy technique. In order to automate and visualize the subviral particles’ motion patterns, previously a tracking algorithm was developed. In this article a new algorithm to parameterize and visualize the achieved particle tracks is introduced. A good potential for a fast data recognition is shown, with constantly respecting a high usability for pharmaceutical researchers. This algorithm was tested on both simulated and real data and provides reproducible results.https://doi.org/10.1515/cdbme-2018-0086fluorescence microscopysubviral particlesmovement patterns |
| spellingShingle | Kaak Michelle Rausch Andreas Müller Dennis Schanze Thomas Visualization and Parametrization of the Motion Behaviour of Subviral Particles Current Directions in Biomedical Engineering fluorescence microscopy subviral particles movement patterns |
| title | Visualization and Parametrization of the Motion Behaviour of Subviral Particles |
| title_full | Visualization and Parametrization of the Motion Behaviour of Subviral Particles |
| title_fullStr | Visualization and Parametrization of the Motion Behaviour of Subviral Particles |
| title_full_unstemmed | Visualization and Parametrization of the Motion Behaviour of Subviral Particles |
| title_short | Visualization and Parametrization of the Motion Behaviour of Subviral Particles |
| title_sort | visualization and parametrization of the motion behaviour of subviral particles |
| topic | fluorescence microscopy subviral particles movement patterns |
| url | https://doi.org/10.1515/cdbme-2018-0086 |
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