Impact of Peptide Structure on Colonic Stability and Tissue Permeability

Impact of Peptide Structure on Colonic Stability and Tissue Permeability

Most marketed peptide drugs are administered parenterally due to their inherent gastrointestinal (GI) instability and poor permeability across the GI epithelium. Several molecular design techniques, such as cyclisation and D-amino acid (D-AA) substitution, have been proposed to improve oral peptide...

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Bibliographic Details
Main Authors: Farhan Taherali, Nerisha Chouhan, Fanjin Wang, Sebastien Lavielle, Maryana Baran, Laura E. McCoubrey, Abdul W. Basit, Vipul Yadav
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
oral delivery of biologics and peptides
colonic drug delivery
peptide design and synthesis
gastrointestinal peptide stability
microbiota drug metabolism
bioavailability of biopharmaceuticals
Online Access:https://www.mdpi.com/1999-4923/15/7/1956

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https://www.mdpi.com/1999-4923/15/7/1956

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