Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy
Chemotherapeutic agents are considered one of the strategies in treating cancer. However, their use is faced by many challenges, such as poor water solubility leading to poor bioavailability and non-selective targeting of cancerous cells leading to diminished therapeutic actions and systemic adverse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/6/292 |
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| author | Sherif Ashraf Fahmy Jana Brüßler Mohamad Alawak Mayyada M. H. El-Sayed Udo Bakowsky Tamer Shoeib |
| author_facet | Sherif Ashraf Fahmy Jana Brüßler Mohamad Alawak Mayyada M. H. El-Sayed Udo Bakowsky Tamer Shoeib |
| author_sort | Sherif Ashraf Fahmy |
| collection | DOAJ |
| description | Chemotherapeutic agents are considered one of the strategies in treating cancer. However, their use is faced by many challenges, such as poor water solubility leading to poor bioavailability and non-selective targeting of cancerous cells leading to diminished therapeutic actions and systemic adverse effects. Many approaches were adopted to overcome these drawbacks and to achieve the targeted delivery of the chemotherapeutic agents to the cancerous cells while minimizing adverse effects. Recently, supramolecular systems such as macrocycles have gained attention in the field of cancer therapy for being able to encapsulate different anticancer drugs via either host-guest complexation or self-assembly leading to a myriad of advantages. This review highlights the most recent studies concerned with the design of such novel systems for cancer therapy. |
| first_indexed | 2024-04-13T09:02:40Z |
| format | Article |
| id | doaj.art-ba234ad7843f446dbff1561240d8b7cd |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T09:02:40Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ba234ad7843f446dbff1561240d8b7cd2022-12-22T02:53:07ZengMDPI AGPharmaceutics1999-49232019-06-0111629210.3390/pharmaceutics11060292pharmaceutics11060292Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer TherapySherif Ashraf Fahmy0Jana Brüßler1Mohamad Alawak2Mayyada M. H. El-Sayed3Udo Bakowsky4Tamer Shoeib5Department of Chemistry, American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, EgyptDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, GermanyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, GermanyDepartment of Chemistry, American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, EgyptDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, GermanyDepartment of Chemistry, American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo 11835, EgyptChemotherapeutic agents are considered one of the strategies in treating cancer. However, their use is faced by many challenges, such as poor water solubility leading to poor bioavailability and non-selective targeting of cancerous cells leading to diminished therapeutic actions and systemic adverse effects. Many approaches were adopted to overcome these drawbacks and to achieve the targeted delivery of the chemotherapeutic agents to the cancerous cells while minimizing adverse effects. Recently, supramolecular systems such as macrocycles have gained attention in the field of cancer therapy for being able to encapsulate different anticancer drugs via either host-guest complexation or self-assembly leading to a myriad of advantages. This review highlights the most recent studies concerned with the design of such novel systems for cancer therapy.https://www.mdpi.com/1999-4923/11/6/292chemotherapysupermolecularanticancer drugsmacrocycles |
| spellingShingle | Sherif Ashraf Fahmy Jana Brüßler Mohamad Alawak Mayyada M. H. El-Sayed Udo Bakowsky Tamer Shoeib Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy Pharmaceutics chemotherapy supermolecular anticancer drugs macrocycles |
| title | Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy |
| title_full | Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy |
| title_fullStr | Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy |
| title_full_unstemmed | Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy |
| title_short | Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy |
| title_sort | chemotherapy based on supramolecular chemistry a promising strategy in cancer therapy |
| topic | chemotherapy supermolecular anticancer drugs macrocycles |
| url | https://www.mdpi.com/1999-4923/11/6/292 |
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