A structural MRI study of cholinergic pathways and cognition in multiple sclerosis
Background: White matter hyperintensities (WMH) in the cholinergic pathways are associated with cognitive performance in Alzheimer's disease. This study aimed to evaluate the relationship between the volume reduction of cholinergic pathways and cognitive function in patients with multiple scler...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | eNeurologicalSci |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650217300254 |
| _version_ | 1818316175261564928 |
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| author | Yukio Kimura Noriko Sato Miho Ota Norihide Maikusa Tomoko Maekawa Daichi Sone Mikako Enokizono Atsuhiko Sugiyama Etsuko Imabayashi Hiroshi Matsuda Tomoko Okamoto Takashi Yamamura Hideharu Sugimoto |
| author_facet | Yukio Kimura Noriko Sato Miho Ota Norihide Maikusa Tomoko Maekawa Daichi Sone Mikako Enokizono Atsuhiko Sugiyama Etsuko Imabayashi Hiroshi Matsuda Tomoko Okamoto Takashi Yamamura Hideharu Sugimoto |
| author_sort | Yukio Kimura |
| collection | DOAJ |
| description | Background: White matter hyperintensities (WMH) in the cholinergic pathways are associated with cognitive performance in Alzheimer's disease. This study aimed to evaluate the relationship between the volume reduction of cholinergic pathways and cognitive function in patients with multiple sclerosis (MS). Methods: Thirty-two MS patients underwent a brain MRI and cognitive measurements including the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J). The extent of WMH within the cholinergic pathways was assessed using the Cholinergic Pathways Hyperintensities Scale (CHIPS). Computerized WMH volumes were also obtained. FreeSurfer was used to measure regional volumes including the cortical and subcortical volumes. The correlations among the CHIPS, the WMH volume, and the clinical data were assessed, in addition to the correlations between the cognitive scores and regional volumes measured by FreeSurfer. Results: The CHIPS score and the WMH volume were strongly positively correlated with each other (r=0.87, P<0.001). The CHIPS score had significantly negative correlations with the MMSE (r=−0.49, P=0.003) and the MoCA-J (r=−0.47, P=0.005) results. The WMH volume had significantly negative correlations with the MMSE (r=−0.54, P=0.001) and the MoCA-J (r=−0.57, P<0.001) results. In the analysis by FreeSurfer, both the MMSE and MoCA-J scores had significant positive correlations only with the volume of the corpus callosum. Conclusions: The CHIPS score tended to be less sensitive to the WMH volume in cognitive function evaluation, although the difference did not reach the level of statistical significance. Thus the CHIPS method may not be as effective in MS patients. Keywords: Multiple sclerosis, CHIPS, Cholinergic pathway, Cognitive impairment |
| first_indexed | 2024-12-13T09:17:15Z |
| format | Article |
| id | doaj.art-ba24f8d9ac9b42a5b37bb73e452a6371 |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-13T09:17:15Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-ba24f8d9ac9b42a5b37bb73e452a63712022-12-21T23:52:49ZengElseviereNeurologicalSci2405-65022017-09-0181116A structural MRI study of cholinergic pathways and cognition in multiple sclerosisYukio Kimura0Noriko Sato1Miho Ota2Norihide Maikusa3Tomoko Maekawa4Daichi Sone5Mikako Enokizono6Atsuhiko Sugiyama7Etsuko Imabayashi8Hiroshi Matsuda9Tomoko Okamoto10Takashi Yamamura11Hideharu Sugimoto12Department of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; Corresponding author at: Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Neurology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Radiology, Jichi Medical University, Shimotsuke, Tochigi, JapanBackground: White matter hyperintensities (WMH) in the cholinergic pathways are associated with cognitive performance in Alzheimer's disease. This study aimed to evaluate the relationship between the volume reduction of cholinergic pathways and cognitive function in patients with multiple sclerosis (MS). Methods: Thirty-two MS patients underwent a brain MRI and cognitive measurements including the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J). The extent of WMH within the cholinergic pathways was assessed using the Cholinergic Pathways Hyperintensities Scale (CHIPS). Computerized WMH volumes were also obtained. FreeSurfer was used to measure regional volumes including the cortical and subcortical volumes. The correlations among the CHIPS, the WMH volume, and the clinical data were assessed, in addition to the correlations between the cognitive scores and regional volumes measured by FreeSurfer. Results: The CHIPS score and the WMH volume were strongly positively correlated with each other (r=0.87, P<0.001). The CHIPS score had significantly negative correlations with the MMSE (r=−0.49, P=0.003) and the MoCA-J (r=−0.47, P=0.005) results. The WMH volume had significantly negative correlations with the MMSE (r=−0.54, P=0.001) and the MoCA-J (r=−0.57, P<0.001) results. In the analysis by FreeSurfer, both the MMSE and MoCA-J scores had significant positive correlations only with the volume of the corpus callosum. Conclusions: The CHIPS score tended to be less sensitive to the WMH volume in cognitive function evaluation, although the difference did not reach the level of statistical significance. Thus the CHIPS method may not be as effective in MS patients. Keywords: Multiple sclerosis, CHIPS, Cholinergic pathway, Cognitive impairmenthttp://www.sciencedirect.com/science/article/pii/S2405650217300254 |
| spellingShingle | Yukio Kimura Noriko Sato Miho Ota Norihide Maikusa Tomoko Maekawa Daichi Sone Mikako Enokizono Atsuhiko Sugiyama Etsuko Imabayashi Hiroshi Matsuda Tomoko Okamoto Takashi Yamamura Hideharu Sugimoto A structural MRI study of cholinergic pathways and cognition in multiple sclerosis eNeurologicalSci |
| title | A structural MRI study of cholinergic pathways and cognition in multiple sclerosis |
| title_full | A structural MRI study of cholinergic pathways and cognition in multiple sclerosis |
| title_fullStr | A structural MRI study of cholinergic pathways and cognition in multiple sclerosis |
| title_full_unstemmed | A structural MRI study of cholinergic pathways and cognition in multiple sclerosis |
| title_short | A structural MRI study of cholinergic pathways and cognition in multiple sclerosis |
| title_sort | structural mri study of cholinergic pathways and cognition in multiple sclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405650217300254 |
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