Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study
Objective: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-02-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1339072 |
| _version_ | 1797681541547032576 |
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| author | Shigehiro Karashima Mitsuhiro Kometani Hiromasa Tsujiguchi Hiroki Asakura Shigeru Nakano Mikiya Usukura Shunsuke Mori Masashi Ohe Toshitaka Sawamura Rika Okuda Akinori Hara Toshinari Takamura Masakazu Yamagishi Hiroyuki Nakamura Yoshiyu Takeda Takashi Yoneda |
| author_facet | Shigehiro Karashima Mitsuhiro Kometani Hiromasa Tsujiguchi Hiroki Asakura Shigeru Nakano Mikiya Usukura Shunsuke Mori Masashi Ohe Toshitaka Sawamura Rika Okuda Akinori Hara Toshinari Takamura Masakazu Yamagishi Hiroyuki Nakamura Yoshiyu Takeda Takashi Yoneda |
| author_sort | Shigehiro Karashima |
| collection | DOAJ |
| description | Objective: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. Methods: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan. Results: Among them, 195 subjects (78 males, mean age: 62 ± 11 years) did not take antihypertensive agents: 113 normotensive subjects and 82 hypertensive subjects. Under these conditions, 68 subjects (13 males, age 62 ± 10 years) had an ARR >200. In 14 subjects who underwent captopril suppression test, PA was documented in 5 subjects, yielding a minimum prevalence of 2.6% in total subjects (1.8% in normotensive subjects and 3.7% in hypertensive subjects). Interestingly, females subjects demonstrated significant differences in ARR between subjects with age <50 (172 ± 105) and those with age 51–60 (388 ± 531), although there were no differences in male subjects. Conclusions: These results demonstrate that PA including normotensive subjects exists more commonly than that expected in the general population. We suggest further investigation about the cause and progression of PA associated with sex and aging. |
| first_indexed | 2024-03-11T23:46:20Z |
| format | Article |
| id | doaj.art-ba250732fcd344a1b31b235e4198e3e8 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:20Z |
| publishDate | 2018-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-ba250732fcd344a1b31b235e4198e3e82023-09-19T09:24:46ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-02-0140211812510.1080/10641963.2017.13390721339072Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika studyShigehiro Karashima0Mitsuhiro Kometani1Hiromasa Tsujiguchi2Hiroki Asakura3Shigeru Nakano4Mikiya Usukura5Shunsuke Mori6Masashi Ohe7Toshitaka Sawamura8Rika Okuda9Akinori Hara10Toshinari Takamura11Masakazu Yamagishi12Hiroyuki Nakamura13Yoshiyu Takeda14Takashi Yoneda15Division of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDepartment of Public Health, Kanazawa University Graduate School of MedicineInternal Medicine, Shika Town Togi Hospital, Hakui-gun Shika-machiInternal Medicine, Shika Clinic, Hakui-gun Shika-machiDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDepartment of Public Health, Kanazawa University Graduate School of MedicineKanazawa University Graduate School of MedicineKanazawa University Graduate School of MedicineDepartment of Public Health, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineDivision of Endocrinology and Metabolism, Kanazawa University Graduate School of MedicineObjective: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. Methods: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan. Results: Among them, 195 subjects (78 males, mean age: 62 ± 11 years) did not take antihypertensive agents: 113 normotensive subjects and 82 hypertensive subjects. Under these conditions, 68 subjects (13 males, age 62 ± 10 years) had an ARR >200. In 14 subjects who underwent captopril suppression test, PA was documented in 5 subjects, yielding a minimum prevalence of 2.6% in total subjects (1.8% in normotensive subjects and 3.7% in hypertensive subjects). Interestingly, females subjects demonstrated significant differences in ARR between subjects with age <50 (172 ± 105) and those with age 51–60 (388 ± 531), although there were no differences in male subjects. Conclusions: These results demonstrate that PA including normotensive subjects exists more commonly than that expected in the general population. We suggest further investigation about the cause and progression of PA associated with sex and aging.http://dx.doi.org/10.1080/10641963.2017.1339072general populationnormotensiveprimary aldosteronismprevalence |
| spellingShingle | Shigehiro Karashima Mitsuhiro Kometani Hiromasa Tsujiguchi Hiroki Asakura Shigeru Nakano Mikiya Usukura Shunsuke Mori Masashi Ohe Toshitaka Sawamura Rika Okuda Akinori Hara Toshinari Takamura Masakazu Yamagishi Hiroyuki Nakamura Yoshiyu Takeda Takashi Yoneda Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study Clinical and Experimental Hypertension general population normotensive primary aldosteronism prevalence |
| title | Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study |
| title_full | Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study |
| title_fullStr | Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study |
| title_full_unstemmed | Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study |
| title_short | Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study |
| title_sort | prevalence of primary aldosteronism without hypertension in the general population results in shika study |
| topic | general population normotensive primary aldosteronism prevalence |
| url | http://dx.doi.org/10.1080/10641963.2017.1339072 |
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